FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

Britta K. Winkler; Hendrik Lehnert; Henrik Oster; Henriette Kirchner; Birgit Harbeck

doi:10.2217/epi-2017-0057

FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

Britta K. Winkler, Hendrik Lehnert, Henrik Oster, Henriette Kirchner, Birgit Harbeck^*

^*Corresponding author for this work

Abstract

Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.

Original language	English
Journal	Epigenomics
Volume	9
Issue number	10
Pages (from-to)	1279-1286
Number of pages	8
ISSN	1750-1911
DOIs	https://doi.org/10.2217/epi-2017-0057
Publication status	Published - 01.10.2017

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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title = "FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects",

abstract = "Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.",

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T1 - FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

AU - Winkler, Britta K.

AU - Lehnert, Hendrik

AU - Oster, Henrik

AU - Kirchner, Henriette

AU - Harbeck, Birgit

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.

AB - Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.

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SN - 1750-1911

VL - 9

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JO - Epigenomics

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FKBP5 methylation as a possible marker for cortisol state and transient cortisol exposure in healthy human subjects

Abstract

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