Current glucocorticoid replacement regimens, in adrenal insufficiency, fail to mimic the physiological cortisol secretion, thereby fostering serious side effects. Aim: To experimentally evaluate the impact of CpG methylation within the FKBP5 gene as a possible short-and long-term marker for cortisol exposure in humans. Materials & methods: An ACTH-stimulation test was carried out and methylation status of the FKBP5 gene in leukocytes was determined. Results: A negative correlation between basal levels of methylation and serum cortisol was observed. Individual changes in FKBP5 methylation after 24 h correlated with cortisol responses. Conclusion: Considering previous studies conducted with murine leucocytes, FKBP5 methylation may be suitable as a long-term biomarker, rather than acute glucocorticoid exposure, also in humans.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)