First Prompt Gamma Timing measurements with carbon ions

Sahar Ranjbar; Emanuele Data; Felix Mas Milian; Davide Bersani; Piergiorgio Cerello; Roberto Cirio; Veronica Ferrero; Mohammad Fadavi Mazinani; Simona Giordanengo; Mohammad Amin Hosseini; Elena Lombardo; Diango Manuel Montalvan-Olivares; Marco Pullia; Simone Savazzi; Roberto Sacchi; Anna Vignati; Julius Werner; Francesco Pennazio; Elisa Fiorina

doi:10.1109/NSS/MIC/RTSD57108.2024.10655573

First Prompt Gamma Timing measurements with carbon ions

Sahar Ranjbar, Emanuele Data, Felix Mas Milian, Davide Bersani, Piergiorgio Cerello, Roberto Cirio, Veronica Ferrero, Mohammad Fadavi Mazinani, Simona Giordanengo, Mohammad Amin Hosseini, Elena Lombardo, Diango Manuel Montalvan-Olivares, Marco Pullia, Simone Savazzi, Roberto Sacchi, Anna Vignati, Julius Werner, Francesco Pennazio, Elisa Fiorina

Institute of Medical Engineering

Abstract

The Prompt Gamma Timing (PGT) method provides the assessment of particle range by measuring the time of flight between the primary particle and PG detection. This non-invasive and real-time approach is a tool to monitor the therapy’s effectiveness and reduce uncertainties in treatment planning. We report the first PGT results obtained with carbon ion beams at the sub-clinical rate at the CNAO (Pavia, IT). The experimental setup relies on a silicon strip sensor to measure the transit time of the primaries and a detector based on a monolithic LaBr3-crystal coupled to a Silicon PhotoMultiplier matrix. Homogeneous and in-homogeneous phantoms have been irradiated with carbon ion beams of energy equal to $398 MeV / u$. The obtained results are promising, and further tests are foreseen to address clinical rates and prove the applicability of this approach to clinics.

Original language	English
Title of host publication	2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD)
Number of pages	1
Publication date	01.10.2024
Pages	1-1
DOIs	https://doi.org/10.1109/NSS/MIC/RTSD57108.2024.10655573
Publication status	Published - 01.10.2024

Research Areas and Centers

Academic Focus: Biomedical Engineering
Centers: Center of Imaging Sciences (CIS)

DFG Research Classification Scheme

2.22-32 Medical Physics, Biomedical Technology

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10.1109/NSS/MIC/RTSD57108.2024.10655573

PROton Stopping power estimation in Ion Therapy (PROSIT)
Rafecas, M. (Principal Investigator (PI)), Ferrero, V. (Principal Investigator (PI)), Hueso-González, F. (Principal Investigator (PI)) & Pennazio, F. (Principal Investigator (PI))
01.01.23 → 31.12.28
Project: DFG Individual Projects

Cite this

Ranjbar, S., Data, E., Milian, F. M., Bersani, D., Cerello, P., Cirio, R., Ferrero, V., Mazinani, M. F., Giordanengo, S., Hosseini, M. A., Lombardo, E., Montalvan-Olivares, D. M., Pullia, M., Savazzi, S., Sacchi, R., Vignati, A., Werner, J., Pennazio, F., & Fiorina, E. (2024). First Prompt Gamma Timing measurements with carbon ions. In 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD) (pp. 1-1) https://doi.org/10.1109/NSS/MIC/RTSD57108.2024.10655573

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title = "First Prompt Gamma Timing measurements with carbon ions",

abstract = "The Prompt Gamma Timing (PGT) method provides the assessment of particle range by measuring the time of flight between the primary particle and PG detection. This non-invasive and real-time approach is a tool to monitor the therapy{\textquoteright}s effectiveness and reduce uncertainties in treatment planning. We report the first PGT results obtained with carbon ion beams at the sub-clinical rate at the CNAO (Pavia, IT). The experimental setup relies on a silicon strip sensor to measure the transit time of the primaries and a detector based on a monolithic LaBr3-crystal coupled to a Silicon PhotoMultiplier matrix. Homogeneous and in-homogeneous phantoms have been irradiated with carbon ion beams of energy equal to \$398 MeV / u\$. The obtained results are promising, and further tests are foreseen to address clinical rates and prove the applicability of this approach to clinics.",

author = "Sahar Ranjbar and Emanuele Data and Milian, \{Felix Mas\} and Davide Bersani and Piergiorgio Cerello and Roberto Cirio and Veronica Ferrero and Mazinani, \{Mohammad Fadavi\} and Simona Giordanengo and Hosseini, \{Mohammad Amin\} and Elena Lombardo and Montalvan-Olivares, \{Diango Manuel\} and Marco Pullia and Simone Savazzi and Roberto Sacchi and Anna Vignati and Julius Werner and Francesco Pennazio and Elisa Fiorina",

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doi = "10.1109/NSS/MIC/RTSD57108.2024.10655573",

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Ranjbar, S, Data, E, Milian, FM, Bersani, D, Cerello, P, Cirio, R, Ferrero, V, Mazinani, MF, Giordanengo, S, Hosseini, MA, Lombardo, E, Montalvan-Olivares, DM, Pullia, M, Savazzi, S, Sacchi, R, Vignati, A, Werner, J, Pennazio, F & Fiorina, E 2024, First Prompt Gamma Timing measurements with carbon ions. in 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD). pp. 1-1. https://doi.org/10.1109/NSS/MIC/RTSD57108.2024.10655573

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T1 - First Prompt Gamma Timing measurements with carbon ions

AU - Ranjbar, Sahar

AU - Data, Emanuele

AU - Milian, Felix Mas

AU - Bersani, Davide

AU - Cerello, Piergiorgio

AU - Cirio, Roberto

AU - Ferrero, Veronica

AU - Mazinani, Mohammad Fadavi

AU - Giordanengo, Simona

AU - Hosseini, Mohammad Amin

AU - Lombardo, Elena

AU - Montalvan-Olivares, Diango Manuel

AU - Pullia, Marco

AU - Savazzi, Simone

AU - Sacchi, Roberto

AU - Vignati, Anna

AU - Werner, Julius

AU - Pennazio, Francesco

AU - Fiorina, Elisa

PY - 2024/10/1

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N2 - The Prompt Gamma Timing (PGT) method provides the assessment of particle range by measuring the time of flight between the primary particle and PG detection. This non-invasive and real-time approach is a tool to monitor the therapy’s effectiveness and reduce uncertainties in treatment planning. We report the first PGT results obtained with carbon ion beams at the sub-clinical rate at the CNAO (Pavia, IT). The experimental setup relies on a silicon strip sensor to measure the transit time of the primaries and a detector based on a monolithic LaBr3-crystal coupled to a Silicon PhotoMultiplier matrix. Homogeneous and in-homogeneous phantoms have been irradiated with carbon ion beams of energy equal to $398 MeV / u$. The obtained results are promising, and further tests are foreseen to address clinical rates and prove the applicability of this approach to clinics.

AB - The Prompt Gamma Timing (PGT) method provides the assessment of particle range by measuring the time of flight between the primary particle and PG detection. This non-invasive and real-time approach is a tool to monitor the therapy’s effectiveness and reduce uncertainties in treatment planning. We report the first PGT results obtained with carbon ion beams at the sub-clinical rate at the CNAO (Pavia, IT). The experimental setup relies on a silicon strip sensor to measure the transit time of the primaries and a detector based on a monolithic LaBr3-crystal coupled to a Silicon PhotoMultiplier matrix. Homogeneous and in-homogeneous phantoms have been irradiated with carbon ion beams of energy equal to $398 MeV / u$. The obtained results are promising, and further tests are foreseen to address clinical rates and prove the applicability of this approach to clinics.

U2 - 10.1109/NSS/MIC/RTSD57108.2024.10655573

DO - 10.1109/NSS/MIC/RTSD57108.2024.10655573

M3 - Conference contribution

SP - 1

EP - 1

BT - 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD)

ER -

First Prompt Gamma Timing measurements with carbon ions

Abstract

Research Areas and Centers

DFG Research Classification Scheme

Access to Document

Projects

PROton Stopping power estimation in Ion Therapy (PROSIT)

Cite this