First-Choice Antibiotics at Subinhibitory Concentrations Induce Persistence of Chlamydia pneumoniae

Jens Gieffers; Jan Rupp; Andreas Gebert; Werner Solbach; Matthias Klinger

doi:10.1128/AAC.48.4.1402-1405.2004

First-Choice Antibiotics at Subinhibitory Concentrations Induce Persistence of Chlamydia pneumoniae

Jens Gieffers^*, Jan Rupp, Andreas Gebert, Werner Solbach, Matthias Klinger

^*Corresponding author for this work

Institute of Anatomy

59 Citations (Scopus)

Abstract

Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	48
Issue number	4
Pages (from-to)	1402-1405
Number of pages	4
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.48.4.1402-1405.2004
Publication status	Published - 01.04.2004

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1128/AAC.48.4.1402-1405.2004

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abstract = "Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.",

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AU - Rupp, Jan

AU - Gebert, Andreas

AU - Solbach, Werner

AU - Klinger, Matthias

PY - 2004/4/1

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AB - Persistent growth forms of Chlamydia pneumoniae have been associated with chronic infections in vivo. We investigated the effects of first-line therapeutics on the induction of persistence by monitoring recoverable organisms, gene expression of membrane proteins, and morphology. We found that all of the antibiotics tested have distinct and subinhibitory concentrations at which they induce persistence.

UR - https://www.scopus.com/pages/publications/1642502276

U2 - 10.1128/AAC.48.4.1402-1405.2004

DO - 10.1128/AAC.48.4.1402-1405.2004

M3 - Journal articles

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First-Choice Antibiotics at Subinhibitory Concentrations Induce Persistence of Chlamydia pneumoniae

Abstract

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