First case of disseminated cryptococcosis in a Gorilla gorilla

Alexander Mischnik; Julia Stockklausner; Nicole Hohneder; Henrik E. Jensen; Stefan Zimmermann; David E. Reuss; Volker Rickerts; Kathrin Tintelnot; Clemens Stockklausner

doi:10.1111/myc.12215

First case of disseminated cryptococcosis in a Gorilla gorilla

Alexander Mischnik^*, Julia Stockklausner, Nicole Hohneder, Henrik E. Jensen, Stefan Zimmermann, David E. Reuss, Volker Rickerts, Kathrin Tintelnot, Clemens Stockklausner

^*Corresponding author for this work

11 Citations (Scopus)

Abstract

Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.

Original language	English
Journal	Mycoses
Volume	57
Issue number	11
Pages (from-to)	664-671
Number of pages	8
ISSN	0933-7407
DOIs	https://doi.org/10.1111/myc.12215
Publication status	Published - 01.11.2014

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1111/myc.12215

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title = "First case of disseminated cryptococcosis in a Gorilla gorilla",

abstract = "Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.",

author = "Alexander Mischnik and Julia Stockklausner and Nicole Hohneder and Jensen, \{Henrik E.\} and Stefan Zimmermann and Reuss, \{David E.\} and Volker Rickerts and Kathrin Tintelnot and Clemens Stockklausner",

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doi = "10.1111/myc.12215",

language = "English",

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T1 - First case of disseminated cryptococcosis in a Gorilla gorilla

AU - Mischnik, Alexander

AU - Stockklausner, Julia

AU - Hohneder, Nicole

AU - Jensen, Henrik E.

AU - Zimmermann, Stefan

AU - Reuss, David E.

AU - Rickerts, Volker

AU - Tintelnot, Kathrin

AU - Stockklausner, Clemens

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.

AB - Summary: In humans, Cryptococcus mainly infects individuals with HIV infection or other types of immunosuppression. Here, we report the first case of disseminated cryptococcosis in a simian immunodeficiency virus-negative 27-year-old female Gorilla gorilla presenting with lethargy, progressive weight loss and productive cough. The diagnosis was confirmed by positive lung biopsy culture, serum cryptococcal antigen, and cerebral histopathology demonstrating encapsulated yeasts. Molecular characterisation of lung culture isolate yielded Cryptococcus neoformans var. grubii. An immune-deficiency could not be demonstrated.

UR - https://www.scopus.com/pages/publications/84907953498

U2 - 10.1111/myc.12215

DO - 10.1111/myc.12215

M3 - Journal articles

C2 - 24963815

AN - SCOPUS:84907953498

SN - 0933-7407

VL - 57

SP - 664

EP - 671

JO - Mycoses

JF - Mycoses

IS - 11

ER -

First case of disseminated cryptococcosis in a Gorilla gorilla

Abstract

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