Fibronektin-Chemotaxis und Kollagengelkontraktion von Fibroblasten aus der Palmaraponeurose beim Morbus Dupuytren

Translated title of the contribution: Fibronectin-chemotaxis and collagen-gel contraction of the palmar aponeurosis in morbus dupuytren

J Hoch, E Felouzis, O Meyer-Walters, B Nebe, H Notbohm

Abstract

Causes for Morbus Dupuytren (MD) on the cellular level are largely unknown. We have studied chemotaxis and collagen-gel contraction of cultivated cells from nodules and cords of Morbus Dupuytren patients and normal palmar aponeurosis. The cells of the seized tissue showed an increased chemotaxis in gradients of the chemo-attractant fibronectin. Furthermore embedded into collagen-gels cells from MD patients especially from the region of cords to the skin had an enhanced ability to contract a three-dimensional collagen network compared to those originating from the center of the nodules and control palmar aponeurosis. One reason for the increase of chemotactic motion and the ability to contract gels could be a surplus of receptors for extracellular matrix proteins (integrins) on the surface of cells from seized tissues. Flow cytometry of cells fluorimetrically stained for beta 1 -, alpha 2 - and alpha 3 -integrins displayed no differences in the quantity of these main cell surface receptors.

Translated title of the contributionFibronectin-chemotaxis and collagen-gel contraction of the palmar aponeurosis in morbus dupuytren
Original languageGerman
JournalHandchirurgie Mikrochirurgie Plastische Chirurgie
Volume34
Issue number5
Pages (from-to)292-7
Number of pages6
ISSN0722-1819
DOIs
Publication statusPublished - 09.2002

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