Fibroblast tissue priming—not so nice to C you!

Behdad Afzali; Claudia Kemper

doi:10.1016/j.immuni.2021.04.010

Fibroblast tissue priming—not so nice to C you!

Behdad Afzali^*, Claudia Kemper

^*Corresponding author for this work

Institute of Systemic Inflamation Research

National Institute of Diabetes and Digestive and Kidney Diseases

Abstract

The molecular mechanisms explaining why relapses of inflammatory arthritis occur at previously affected sites are unknown. In this issue of Immunity, Friščić et al. propose that local fibroblasts perpetuate inflammation after priming through cell-intrinsic complement C3, which reprograms their bioenergetics and activates the inflammasome.

Original language	English
Journal	Immunity
Volume	54
Issue number	5
Pages (from-to)	847-850
Number of pages	4
ISSN	1074-7613
DOIs	https://doi.org/10.1016/j.immuni.2021.04.010
Publication status	Published - 11.05.2021

Funding

This work was supported in part by the Intramural Research Program of the NIH , the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (project number ZIA/DK075149 to B.A.) and the National Heart, Lung, and Blood Institute (NHLBI) (project number ZIA/Hl006223 to C.K.).

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2021.04.010

Cite this

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abstract = "The molecular mechanisms explaining why relapses of inflammatory arthritis occur at previously affected sites are unknown. In this issue of Immunity, Fri{\v s}{\v c}i{\'c} et al. propose that local fibroblasts perpetuate inflammation after priming through cell-intrinsic complement C3, which reprograms their bioenergetics and activates the inflammasome.",

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AU - Kemper, Claudia

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AB - The molecular mechanisms explaining why relapses of inflammatory arthritis occur at previously affected sites are unknown. In this issue of Immunity, Friščić et al. propose that local fibroblasts perpetuate inflammation after priming through cell-intrinsic complement C3, which reprograms their bioenergetics and activates the inflammasome.

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M3 - Journal articles

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Fibroblast tissue priming—not so nice to C you!

Abstract

Funding

Research Areas and Centers

UN SDGs

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