Fibroblast tissue priming—not so nice to C you!

Behdad Afzali*, Claudia Kemper

*Corresponding author for this work

Abstract

The molecular mechanisms explaining why relapses of inflammatory arthritis occur at previously affected sites are unknown. In this issue of Immunity, Friščić et al. propose that local fibroblasts perpetuate inflammation after priming through cell-intrinsic complement C3, which reprograms their bioenergetics and activates the inflammasome.

Original languageEnglish
JournalImmunity
Volume54
Issue number5
Pages (from-to)847-850
Number of pages4
ISSN1074-7613
DOIs
Publication statusPublished - 11.05.2021

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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