FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area

von Mässenhausen Anne von Mässenhausen; Alina Franzen; Lynn Heasley; Sven Perner

doi:10.3978/j.issn.2305-5839.2013.06.08

FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area

von Mässenhausen Anne von Mässenhausen, Alina Franzen, Lynn Heasley, Sven Perner^*

^*Corresponding author for this work

Institute of Pathology

20 Citations (Scopus)

Abstract

FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.

Original language	English
Article number	23
Journal	Annals of Translational Medicine
Volume	1
Issue number	3
ISSN	2305-5839
DOIs	https://doi.org/10.3978/j.issn.2305-5839.2013.06.08
Publication status	Published - 10.2013

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SDG 3 Good Health and Well-being

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10.3978/j.issn.2305-5839.2013.06.08

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abstract = "FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.",

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AU - Anne von Mässenhausen, von Mässenhausen

AU - Franzen, Alina

AU - Heasley, Lynn

AU - Perner, Sven

PY - 2013/10

Y1 - 2013/10

N2 - FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.

AB - FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.

UR - https://www.scopus.com/pages/publications/85015480807

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DO - 10.3978/j.issn.2305-5839.2013.06.08

M3 - Editorial

AN - SCOPUS:85015480807

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JO - Annals of Translational Medicine

JF - Annals of Translational Medicine

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FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area

Abstract

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