TY - JOUR
T1 - FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area
AU - Anne von Mässenhausen, von Mässenhausen
AU - Franzen, Alina
AU - Heasley, Lynn
AU - Perner, Sven
N1 - Publisher Copyright:
© Annals of Translational Medicine.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2013/10
Y1 - 2013/10
N2 - FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.
AB - FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.
UR - http://www.scopus.com/inward/record.url?scp=85015480807&partnerID=8YFLogxK
U2 - 10.3978/j.issn.2305-5839.2013.06.08
DO - 10.3978/j.issn.2305-5839.2013.06.08
M3 - Editorial
AN - SCOPUS:85015480807
SN - 2305-5839
VL - 1
JO - Annals of Translational Medicine
JF - Annals of Translational Medicine
IS - 3
M1 - 23
ER -