FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area

von Mässenhausen Anne von Mässenhausen, Alina Franzen, Lynn Heasley, Sven Perner*

*Corresponding author for this work
9 Citations (Scopus)

Abstract

FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.

Original languageEnglish
Article number23
JournalAnnals of Translational Medicine
Volume1
Issue number3
ISSN2305-5839
DOIs
Publication statusPublished - 10.2013

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