Fetale Thrombophilie: Eine zu wenig beachtete Risikokonstellation?

Recent findings suggest that inherited or acquired maternal thrombophilic disorders lead to recurrent fetal loss, preeclampsia, intrauterine growth restriction and placental abruption. On the fetal side, there is a growing body of evidence that fetal thrombophilia is closely related to catastrophic perinatal events, such as stroke (resulting in cerebral palsy) or limb ischemia via arterial thrombosis, cerebral sinus venosus thrombosis or renal vein thrombosis. Furthermore, an association between fetal thrombophilia and adverse pregnancy outcome has been reported. Fetal thrombotic vasculopathy has been assumed to be a plausible underlying cause for placental lesions and neonatal sequelae. This review aims to tabulate and discuss the findings regarding the weight of fetal thrombophilic factors and the potential association with obstetric and neonatal complications derived from the current literature.