TY - JOUR
T1 - Fecal Microbiota Transplantation (FMT) as an Adjunctive Therapy for Depression—Case Report
AU - Doll, Jessica P.K.
AU - Vázquez-Castellanos, Jorge F.
AU - Schaub, Anna Chiara
AU - Schweinfurth, Nina
AU - Kettelhack, Cedric
AU - Schneider, Else
AU - Yamanbaeva, Gulnara
AU - Mählmann, Laura
AU - Brand, Serge
AU - Beglinger, Christoph
AU - Borgwardt, Stefan
AU - Raes, Jeroen
AU - Schmidt, André
AU - Lang, Undine E.
N1 - Publisher Copyright:
Copyright © 2022 Doll, Vázquez-Castellanos, Schaub, Schweinfurth, Kettelhack, Schneider, Yamanbaeva, Mählmann, Brand, Beglinger, Borgwardt, Raes, Schmidt and Lang.
PY - 2022/2/17
Y1 - 2022/2/17
N2 - Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.
AB - Depression is a debilitating disorder, and at least one third of patients do not respond to therapy. Associations between gut microbiota and depression have been observed in recent years, opening novel treatment avenues. Here, we present the first two patients with major depressive disorder ever treated with fecal microbiota transplantation as add-on therapy. Both improved their depressive symptoms 4 weeks after the transplantation. Effects lasted up to 8 weeks in one patient. Gastrointestinal symptoms, constipation in particular, were reflected in microbiome changes and improved in one patient. This report suggests further FMT studies in depression could be worth pursuing and adds to awareness as well as safety assurance, both crucial in determining the potential of FMT in depression treatment.
UR - http://www.scopus.com/inward/record.url?scp=85125701122&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2022.815422
DO - 10.3389/fpsyt.2022.815422
M3 - Journal articles
C2 - 35250668
AN - SCOPUS:85125701122
VL - 13
SP - 815422
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
SN - 1664-0640
M1 - 815422
ER -