Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin

H. P. Hauber; J. Galle; P. L. Chiodini; J. Rupp; R. Birke; E. Vollmer; P. Zabel; C. Lange

doi:10.1007/s15010-005-5060-x

Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin

H. P. Hauber, J. Galle, P. L. Chiodini, J. Rupp, R. Birke, E. Vollmer, P. Zabel, C. Lange^*

^*Corresponding author for this work

37 Citations (Scopus)

Abstract

We report the case of a 77-year-oLd man who developed a Strongyloides hyperinfection syndrome following immunosuppressive therapy more than 60 years after he moved away from an area endemic for Strongyloides stercoralis. Successful eradication of the nematode was achieved with an off label subcutaneous formulation of ivermectin. However, the patient subsequently died from acute respiratory distress syndrome (ARDS). Despite a high wormload in the stool and sputum of the patient and delayed infection control measures in the hospital, testing of the medical staff revealed a very low risk of Strongyloides transmission among healthcare workers.

Original language	English
Journal	Infection
Volume	33
Issue number	5-6
Pages (from-to)	383-386
Number of pages	4
ISSN	0300-8126
DOIs	https://doi.org/10.1007/s15010-005-5060-x
Publication status	Published - 01.10.2005

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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title = "Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin",

abstract = "We report the case of a 77-year-oLd man who developed a Strongyloides hyperinfection syndrome following immunosuppressive therapy more than 60 years after he moved away from an area endemic for Strongyloides stercoralis. Successful eradication of the nematode was achieved with an off label subcutaneous formulation of ivermectin. However, the patient subsequently died from acute respiratory distress syndrome (ARDS). Despite a high wormload in the stool and sputum of the patient and delayed infection control measures in the hospital, testing of the medical staff revealed a very low risk of Strongyloides transmission among healthcare workers.",

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AU - Hauber, H. P.

AU - Galle, J.

AU - Chiodini, P. L.

AU - Rupp, J.

AU - Birke, R.

AU - Vollmer, E.

AU - Zabel, P.

AU - Lange, C.

PY - 2005/10/1

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N2 - We report the case of a 77-year-oLd man who developed a Strongyloides hyperinfection syndrome following immunosuppressive therapy more than 60 years after he moved away from an area endemic for Strongyloides stercoralis. Successful eradication of the nematode was achieved with an off label subcutaneous formulation of ivermectin. However, the patient subsequently died from acute respiratory distress syndrome (ARDS). Despite a high wormload in the stool and sputum of the patient and delayed infection control measures in the hospital, testing of the medical staff revealed a very low risk of Strongyloides transmission among healthcare workers.

AB - We report the case of a 77-year-oLd man who developed a Strongyloides hyperinfection syndrome following immunosuppressive therapy more than 60 years after he moved away from an area endemic for Strongyloides stercoralis. Successful eradication of the nematode was achieved with an off label subcutaneous formulation of ivermectin. However, the patient subsequently died from acute respiratory distress syndrome (ARDS). Despite a high wormload in the stool and sputum of the patient and delayed infection control measures in the hospital, testing of the medical staff revealed a very low risk of Strongyloides transmission among healthcare workers.

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SN - 0300-8126

VL - 33

SP - 383

EP - 386

JO - Infection

JF - Infection

IS - 5-6

ER -

Fatal outcome of a hyperinfection syndrome despite successful eradication of Strongyloides with subcutaneous ivermectin

Abstract

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