Abstract
Although modern anticancer drugs have made great progress in disease treatment, the occurrence of drug resistance often leads to treatment failure. Understanding the molecular basis of resistance mechanisms is important to determine prognosis and develop strategies for circumvention. In this context, subcellular vesicles released by cancer cells have been identified to mediate cellular resistance by various mechanisms. Such extracellular vesicles (EVs) can be subdivided into exosomes and ectosomes based on their size, cargo, and mechanism of formation. The unveiling of EV-targeted treatment options depends on a sound knowledge on EV biology including biogenesis, release, targeting to recipient cells, and uptake. In this review, we focus on EVs as mediators of cancer drug resistance with a particular emphasis on the distinction of exosomes and ectosomes.
| Original language | English |
|---|---|
| Journal | Anticancer Research |
| Volume | 39 |
| Issue number | 7 |
| Pages (from-to) | 3395-3404 |
| Number of pages | 10 |
| ISSN | 0250-7005 |
| DOIs | |
| Publication status | Published - 2019 |
Funding
This contribution was selected by the EORTC-PAMM Group for oral presentation at the 40th EORTC-PAMM Winter Meeting organized by Andrea Bonetti in Verona, Italy in February 2019. We thank Rajam Csordas for her excellent English editing. This project was supported in part by Anelise-Asmussen-Stiftung, Luebeck (grant 180802), LEO Pharma Germany (grant 180208).
