Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

Amir Mehdizadeh; Mohammad Hossein Somi; Masoud Darabi; Mortaza Jabbarpour-Bonyadi

doi:10.1007/s11033-016-3943-9

Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

Amir Mehdizadeh, Mohammad Hossein Somi, Masoud Darabi, Mortaza Jabbarpour-Bonyadi^*

^*Corresponding author for this work

Clinic of Hematology and Oncology

26 Citations (Scopus)

Abstract

Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.

Original language	English
Journal	Molecular Biology Reports
Volume	43
Issue number	2
Pages (from-to)	107-116
Number of pages	10
ISSN	0301-4851
DOIs	https://doi.org/10.1007/s11033-016-3943-9
Publication status	Published - 01.02.2016

Funding

This work has been done as part of the PhD Dissertation for Amir Mehdizadeh. This study was supported by Liver and Gastrointestinal Diseases Research Center at Tabriz University of Medical Sciences (Iran; Grant number: 131/216). Authors would like to acknowledge Stem Cell Research Center at Tabriz University of Medical Sciences (Iran) for their great help.

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abstract = "Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.",

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AU - Jabbarpour-Bonyadi, Mortaza

N1 - Funding Information: This work has been done as part of the PhD Dissertation for Amir Mehdizadeh. This study was supported by Liver and Gastrointestinal Diseases Research Center at Tabriz University of Medical Sciences (Iran; Grant number: 131/216). Authors would like to acknowledge Stem Cell Research Center at Tabriz University of Medical Sciences (Iran) for their great help. Publisher Copyright: © 2016, Springer Science+Business Media Dordrecht.

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AB - Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.

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Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

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