TY - JOUR
T1 - Extracellular signal-regulated kinase 1 and 2 in cancer therapy
T2 - a focus on hepatocellular carcinoma
AU - Mehdizadeh, Amir
AU - Somi, Mohammad Hossein
AU - Darabi, Masoud
AU - Jabbarpour-Bonyadi, Mortaza
N1 - Funding Information:
This work has been done as part of the PhD Dissertation for Amir Mehdizadeh. This study was supported by Liver and Gastrointestinal Diseases Research Center at Tabriz University of Medical Sciences (Iran; Grant number: 131/216). Authors would like to acknowledge Stem Cell Research Center at Tabriz University of Medical Sciences (Iran) for their great help.
Publisher Copyright:
© 2016, Springer Science+Business Media Dordrecht.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.
AB - Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.
UR - http://www.scopus.com/inward/record.url?scp=84958164814&partnerID=8YFLogxK
U2 - 10.1007/s11033-016-3943-9
DO - 10.1007/s11033-016-3943-9
M3 - Scientific review articles
C2 - 26767647
AN - SCOPUS:84958164814
SN - 0301-4851
VL - 43
SP - 107
EP - 116
JO - Molecular biology reports
JF - Molecular biology reports
IS - 2
ER -
