Abstract
The serine/threonine protein kinase D (PKD) family comprises of three members, PKD1 (PKCμ), PKD2 and PKD3 (PKCν). Like the related C-type protein kinases (PKCs), PKDs are activated by diacylglycerol (DAG). PKDs have been implicated in numerous intracellular signaling pathways including vesicular transport, cell proliferation, survival, migration and immune responses. While experimental data on this recently discovered kinase family are starting to accumulate family member specific information is still sparse and only small effort has been taken to functionally differentiate the three PKDs. To address this issue we followed the expression patterns of PKD1, 2 and 3 during the development of the mouse embryo. Using specific probe sets for RT-PCR and in situ hybridization, we demonstrate shared and differential expression domains for the three PKD family members in both neuronal and non-neuronal tissues.
| Original language | English |
|---|---|
| Journal | Gene Expression Patterns |
| Volume | 6 |
| Issue number | 4 |
| Pages (from-to) | 400-408 |
| Number of pages | 9 |
| ISSN | 1567-133X |
| DOIs | |
| Publication status | Published - 01.04.2006 |
Funding
We would like to thank Mrs Doreen Deimer and Mrs Polina Spies for excellent technical assistance and Drs Axel Visel and Lars Geffers for critical comments on the manuscript. H.O. was supported by the EU grant QLG3-CT-2002-01829.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
