Expression of the protein kinase D (PKD) family during mouse embryogenesis

Henrik Oster; Diya Abraham; Michael Leitges

doi:10.1016/j.modgep.2005.09.006

Expression of the protein kinase D (PKD) family during mouse embryogenesis

Henrik Oster^*, Diya Abraham, Michael Leitges

^*Corresponding author for this work

Institute of Neurobiology

30 Citations (Scopus)

Abstract

The serine/threonine protein kinase D (PKD) family comprises of three members, PKD1 (PKCμ), PKD2 and PKD3 (PKCν). Like the related C-type protein kinases (PKCs), PKDs are activated by diacylglycerol (DAG). PKDs have been implicated in numerous intracellular signaling pathways including vesicular transport, cell proliferation, survival, migration and immune responses. While experimental data on this recently discovered kinase family are starting to accumulate family member specific information is still sparse and only small effort has been taken to functionally differentiate the three PKDs. To address this issue we followed the expression patterns of PKD1, 2 and 3 during the development of the mouse embryo. Using specific probe sets for RT-PCR and in situ hybridization, we demonstrate shared and differential expression domains for the three PKD family members in both neuronal and non-neuronal tissues.

Original language	English
Journal	Gene Expression Patterns
Volume	6
Issue number	4
Pages (from-to)	400-408
Number of pages	9
ISSN	1567-133X
DOIs	https://doi.org/10.1016/j.modgep.2005.09.006
Publication status	Published - 01.04.2006

Funding

We would like to thank Mrs Doreen Deimer and Mrs Polina Spies for excellent technical assistance and Drs Axel Visel and Lars Geffers for critical comments on the manuscript. H.O. was supported by the EU grant QLG3-CT-2002-01829.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 8 Decent Work and Economic Growth
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/j.modgep.2005.09.006

Cite this

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title = "Expression of the protein kinase D (PKD) family during mouse embryogenesis",

abstract = "The serine/threonine protein kinase D (PKD) family comprises of three members, PKD1 (PKCμ), PKD2 and PKD3 (PKCν). Like the related C-type protein kinases (PKCs), PKDs are activated by diacylglycerol (DAG). PKDs have been implicated in numerous intracellular signaling pathways including vesicular transport, cell proliferation, survival, migration and immune responses. While experimental data on this recently discovered kinase family are starting to accumulate family member specific information is still sparse and only small effort has been taken to functionally differentiate the three PKDs. To address this issue we followed the expression patterns of PKD1, 2 and 3 during the development of the mouse embryo. Using specific probe sets for RT-PCR and in situ hybridization, we demonstrate shared and differential expression domains for the three PKD family members in both neuronal and non-neuronal tissues.",

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AU - Oster, Henrik

AU - Abraham, Diya

AU - Leitges, Michael

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N2 - The serine/threonine protein kinase D (PKD) family comprises of three members, PKD1 (PKCμ), PKD2 and PKD3 (PKCν). Like the related C-type protein kinases (PKCs), PKDs are activated by diacylglycerol (DAG). PKDs have been implicated in numerous intracellular signaling pathways including vesicular transport, cell proliferation, survival, migration and immune responses. While experimental data on this recently discovered kinase family are starting to accumulate family member specific information is still sparse and only small effort has been taken to functionally differentiate the three PKDs. To address this issue we followed the expression patterns of PKD1, 2 and 3 during the development of the mouse embryo. Using specific probe sets for RT-PCR and in situ hybridization, we demonstrate shared and differential expression domains for the three PKD family members in both neuronal and non-neuronal tissues.

AB - The serine/threonine protein kinase D (PKD) family comprises of three members, PKD1 (PKCμ), PKD2 and PKD3 (PKCν). Like the related C-type protein kinases (PKCs), PKDs are activated by diacylglycerol (DAG). PKDs have been implicated in numerous intracellular signaling pathways including vesicular transport, cell proliferation, survival, migration and immune responses. While experimental data on this recently discovered kinase family are starting to accumulate family member specific information is still sparse and only small effort has been taken to functionally differentiate the three PKDs. To address this issue we followed the expression patterns of PKD1, 2 and 3 during the development of the mouse embryo. Using specific probe sets for RT-PCR and in situ hybridization, we demonstrate shared and differential expression domains for the three PKD family members in both neuronal and non-neuronal tissues.

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Expression of the protein kinase D (PKD) family during mouse embryogenesis

Abstract

Funding

UN SDGs

Research Areas and Centers

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