Expression of the atypical protein kinase C (aPKC) isoforms ι/λ and ζ during mouse embryogenesis

Judit Kovac*, Henrik Oster, Michael Leitges

*Corresponding author for this work
19 Citations (Scopus)


The atypical C-type protein kinases (aPKCs) comprise the third subclass of the PKC family functionally defined by insensitivity to phorbol esters, diacylgylcerol and calcium. aPKCs have been implicated in numerous biological processes including cell proliferation and survival, cell polarity, migration and inflammation. However, only insufficient data exist with regard to aPKC isoform specificity, since both mammalian aPKCs, PKC ι/λ and PKC ζ, exhibit a high structural homology and very similar biochemical properties. In this study, we therefore used isoform-specific riboprobes and antibodies to define the characteristic expression profile of each aPKC isoform during mouse embryogenesis. Both, PKC ι/λ and ζ show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms.

Original languageEnglish
JournalGene Expression Patterns
Issue number1-2
Pages (from-to)187-196
Number of pages10
Publication statusPublished - 01.01.2007

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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