Expression of the atypical protein kinase C (aPKC) isoforms ι/λ and ζ during mouse embryogenesis

Judit Kovac; Henrik Oster; Michael Leitges

doi:10.1016/j.modgep.2006.07.002

Expression of the atypical protein kinase C (aPKC) isoforms ι/λ and ζ during mouse embryogenesis

Judit Kovac^*, Henrik Oster, Michael Leitges

^*Corresponding author for this work

Institute of Neurobiology

19 Citations (Scopus)

Abstract

The atypical C-type protein kinases (aPKCs) comprise the third subclass of the PKC family functionally defined by insensitivity to phorbol esters, diacylgylcerol and calcium. aPKCs have been implicated in numerous biological processes including cell proliferation and survival, cell polarity, migration and inflammation. However, only insufficient data exist with regard to aPKC isoform specificity, since both mammalian aPKCs, PKC ι/λ and PKC ζ, exhibit a high structural homology and very similar biochemical properties. In this study, we therefore used isoform-specific riboprobes and antibodies to define the characteristic expression profile of each aPKC isoform during mouse embryogenesis. Both, PKC ι/λ and ζ show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms.

Original language	English
Journal	Gene Expression Patterns
Volume	7
Issue number	1-2
Pages (from-to)	187-196
Number of pages	10
ISSN	1567-133X
DOIs	https://doi.org/10.1016/j.modgep.2006.07.002
Publication status	Published - 01.01.2007

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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title = "Expression of the atypical protein kinase C (aPKC) isoforms ι/λ and ζ during mouse embryogenesis",

abstract = "The atypical C-type protein kinases (aPKCs) comprise the third subclass of the PKC family functionally defined by insensitivity to phorbol esters, diacylgylcerol and calcium. aPKCs have been implicated in numerous biological processes including cell proliferation and survival, cell polarity, migration and inflammation. However, only insufficient data exist with regard to aPKC isoform specificity, since both mammalian aPKCs, PKC ι/λ and PKC ζ, exhibit a high structural homology and very similar biochemical properties. In this study, we therefore used isoform-specific riboprobes and antibodies to define the characteristic expression profile of each aPKC isoform during mouse embryogenesis. Both, PKC ι/λ and ζ show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms.",

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T1 - Expression of the atypical protein kinase C (aPKC) isoforms ι/λ and ζ during mouse embryogenesis

AU - Kovac, Judit

AU - Oster, Henrik

AU - Leitges, Michael

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N2 - The atypical C-type protein kinases (aPKCs) comprise the third subclass of the PKC family functionally defined by insensitivity to phorbol esters, diacylgylcerol and calcium. aPKCs have been implicated in numerous biological processes including cell proliferation and survival, cell polarity, migration and inflammation. However, only insufficient data exist with regard to aPKC isoform specificity, since both mammalian aPKCs, PKC ι/λ and PKC ζ, exhibit a high structural homology and very similar biochemical properties. In this study, we therefore used isoform-specific riboprobes and antibodies to define the characteristic expression profile of each aPKC isoform during mouse embryogenesis. Both, PKC ι/λ and ζ show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms.

AB - The atypical C-type protein kinases (aPKCs) comprise the third subclass of the PKC family functionally defined by insensitivity to phorbol esters, diacylgylcerol and calcium. aPKCs have been implicated in numerous biological processes including cell proliferation and survival, cell polarity, migration and inflammation. However, only insufficient data exist with regard to aPKC isoform specificity, since both mammalian aPKCs, PKC ι/λ and PKC ζ, exhibit a high structural homology and very similar biochemical properties. In this study, we therefore used isoform-specific riboprobes and antibodies to define the characteristic expression profile of each aPKC isoform during mouse embryogenesis. Both, PKC ι/λ and ζ show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms.

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Expression of the atypical protein kinase C (aPKC) isoforms ι/λ and ζ during mouse embryogenesis

Abstract

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