Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats

Fatimunnisa Qadri; Eva Stark; Walter Häuser; Olaf Jöhren; Andreas Dendorfer; Peter Dominiak

doi:10.1016/j.intimp.2004.02.005

Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats

Fatimunnisa Qadri^*, Eva Stark, Walter Häuser, Olaf Jöhren, Andreas Dendorfer, Peter Dominiak

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

University of Kiel

8 Citations (Scopus)

Abstract

mRNA levels of kinin B₁ and B₂ receptors were determined in HPA axis of type 1 (STZ-induced) and type 2 diabetic rats (ZDF and obese Zucker rats). B₂ mRNA levels were elevated in hypothalamus of STZ-induced diabetic (STZ-D) and ZDF rats. Pituitary B₂ mRNA levels were elevated in ZDF and obese rats. Adrenal B₂ mRNA level was attenuated in STZ-D rats. Kinin B₁ receptor may not play a role in HPA axis in diabetes since its expression was unchanged. Enhanced mRNA expression of B₂ receptors in hypothalamus of STZ-D and ZDF rats parallels a rise in plasma glucose and reflect a functional relationship. Enhanced pituitary B₂ mRNA in type 2 and reduced adrenal in type 1 diabetes account for a differential pattern in release of transmitters.

Original language	English
Journal	International Immunopharmacology
Volume	4
Issue number	4
Pages (from-to)	571-576
Number of pages	6
ISSN	1567-5769
DOIs	https://doi.org/10.1016/j.intimp.2004.02.005
Publication status	Published - 01.04.2004

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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title = "Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats",

abstract = "mRNA levels of kinin B1 and B2 receptors were determined in HPA axis of type 1 (STZ-induced) and type 2 diabetic rats (ZDF and obese Zucker rats). B2 mRNA levels were elevated in hypothalamus of STZ-induced diabetic (STZ-D) and ZDF rats. Pituitary B2 mRNA levels were elevated in ZDF and obese rats. Adrenal B2 mRNA level was attenuated in STZ-D rats. Kinin B1 receptor may not play a role in HPA axis in diabetes since its expression was unchanged. Enhanced mRNA expression of B2 receptors in hypothalamus of STZ-D and ZDF rats parallels a rise in plasma glucose and reflect a functional relationship. Enhanced pituitary B2 mRNA in type 2 and reduced adrenal in type 1 diabetes account for a differential pattern in release of transmitters.",

author = "Fatimunnisa Qadri and Eva Stark and Walter H{\"a}user and Olaf J{\"o}hren and Andreas Dendorfer and Peter Dominiak",

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language = "English",

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T1 - Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats

AU - Qadri, Fatimunnisa

AU - Stark, Eva

AU - Häuser, Walter

AU - Jöhren, Olaf

AU - Dendorfer, Andreas

AU - Dominiak, Peter

PY - 2004/4/1

Y1 - 2004/4/1

N2 - mRNA levels of kinin B1 and B2 receptors were determined in HPA axis of type 1 (STZ-induced) and type 2 diabetic rats (ZDF and obese Zucker rats). B2 mRNA levels were elevated in hypothalamus of STZ-induced diabetic (STZ-D) and ZDF rats. Pituitary B2 mRNA levels were elevated in ZDF and obese rats. Adrenal B2 mRNA level was attenuated in STZ-D rats. Kinin B1 receptor may not play a role in HPA axis in diabetes since its expression was unchanged. Enhanced mRNA expression of B2 receptors in hypothalamus of STZ-D and ZDF rats parallels a rise in plasma glucose and reflect a functional relationship. Enhanced pituitary B2 mRNA in type 2 and reduced adrenal in type 1 diabetes account for a differential pattern in release of transmitters.

AB - mRNA levels of kinin B1 and B2 receptors were determined in HPA axis of type 1 (STZ-induced) and type 2 diabetic rats (ZDF and obese Zucker rats). B2 mRNA levels were elevated in hypothalamus of STZ-induced diabetic (STZ-D) and ZDF rats. Pituitary B2 mRNA levels were elevated in ZDF and obese rats. Adrenal B2 mRNA level was attenuated in STZ-D rats. Kinin B1 receptor may not play a role in HPA axis in diabetes since its expression was unchanged. Enhanced mRNA expression of B2 receptors in hypothalamus of STZ-D and ZDF rats parallels a rise in plasma glucose and reflect a functional relationship. Enhanced pituitary B2 mRNA in type 2 and reduced adrenal in type 1 diabetes account for a differential pattern in release of transmitters.

UR - https://www.scopus.com/pages/publications/16544364807

U2 - 10.1016/j.intimp.2004.02.005

DO - 10.1016/j.intimp.2004.02.005

M3 - Journal articles

C2 - 15171237

AN - SCOPUS:16544364807

SN - 1567-5769

VL - 4

SP - 571

EP - 576

JO - International Immunopharmacology

JF - International Immunopharmacology

IS - 4

ER -

Expression of kinin receptor mRNA in the HPA axis of type 1 and type 2 diabetic rats

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