Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion

Friederike Hoellen; Annika Waldmann; Constanze Banz-Jansen; Achim Rody; Maria Heide; Frank Köster; Julika Ribbat-Idel; Christoph Thorns; Maximilian Gebhard; Martina Oberländer; Jens K. Habermann; Marc Thill

doi:10.3892/ol.2016.4925

Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion

Friederike Hoellen^*, Annika Waldmann, Constanze Banz-Jansen, Achim Rody, Maria Heide, Frank Köster, Julika Ribbat-Idel, Christoph Thorns, Maximilian Gebhard, Martina Oberländer, Jens K. Habermann, Marc Thill

^*Corresponding author for this work

University of Kiel

12 Citations (Scopus)

Abstract

Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.

Original language	English
Journal	Oncology Letters
Volume	12
Issue number	4
Pages (from-to)	2351-2356
Number of pages	6
ISSN	1792-1074
DOIs	https://doi.org/10.3892/ol.2016.4925
Publication status	Published - 01.10.2016

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Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)
Research Area: Center for Population Medicine and Public Health (ZBV)

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10.3892/ol.2016.4925

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title = "Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion",

abstract = "Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23\%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.",

author = "Friederike Hoellen and Annika Waldmann and Constanze Banz-Jansen and Achim Rody and Maria Heide and Frank K{\"o}ster and Julika Ribbat-Idel and Christoph Thorns and Maximilian Gebhard and Martina Oberl{\"a}nder and Habermann, \{Jens K.\} and Marc Thill",

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doi = "10.3892/ol.2016.4925",

language = "English",

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T1 - Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion

AU - Hoellen, Friederike

AU - Waldmann, Annika

AU - Banz-Jansen, Constanze

AU - Rody, Achim

AU - Heide, Maria

AU - Köster, Frank

AU - Ribbat-Idel, Julika

AU - Thorns, Christoph

AU - Gebhard, Maximilian

AU - Oberländer, Martina

AU - Habermann, Jens K.

AU - Thill, Marc

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.

AB - Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.

UR - https://www.scopus.com/pages/publications/84983411155

U2 - 10.3892/ol.2016.4925

DO - 10.3892/ol.2016.4925

M3 - Journal articles

AN - SCOPUS:84983411155

SN - 1792-1074

VL - 12

SP - 2351

EP - 2356

JO - Oncology Letters

JF - Oncology Letters

IS - 4

ER -

Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion

Abstract

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