Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion

Friederike Hoellen*, Annika Waldmann, Constanze Banz-Jansen, Achim Rody, Maria Heide, Frank Köster, Julika Ribbat-Idel, Christoph Thorns, Maximilian Gebhard, Martina Oberländer, Jens K. Habermann, Marc Thill

*Corresponding author for this work
2 Citations (Scopus)


Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.

Original languageEnglish
JournalOncology Letters
Issue number4
Pages (from-to)2351-2356
Number of pages6
Publication statusPublished - 01.10.2016

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Research Area: Center for Population Medicine and Public Health (ZBV)


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