Excessively increased CSF glutamate levels in GABA                                                 B                                                 -receptor antibody associated encephalitis: A case report

Andreas Moser; Henrike Hanssen; Klaus Peter Wandinger

doi:10.1016/j.jns.2018.02.041

Excessively increased CSF glutamate levels in GABA _B -receptor antibody associated encephalitis: A case report

Andreas Moser, Henrike Hanssen, Klaus Peter Wandinger^*

^*Corresponding author for this work

3 Citations (Scopus)

Abstract

Limbic encephalitis (LE) is a rare and rather variable disease associated in part with different antibodies. The most frequent antibodies found are directed against NMDA-receptors or proteins of the voltage-gated potassium channels (LGI1, CASPR2). Additionally, in those patients suffering from LE with early and predominant seizures GABAB-receptor (GABAB-R) antibodies could be identified in serum and cerebrospinal fluid (CSF) [1]. Since blockade of GABAB-R leads to disinhibition [2], the question was raised whether the CSF profile of excitatory and inhibitory neurotransmitters is reflecting pathophysiological mechanisms of the disease.

Original language	English
Journal	Journal of the Neurological Sciences
Volume	388
Pages (from-to)	10-11
Number of pages	2
ISSN	0022-510X
DOIs	https://doi.org/10.1016/j.jns.2018.02.041
Publication status	Published - 15.05.2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Access to Document

10.1016/j.jns.2018.02.041

Cite this

@article{5085f54564254b10866f22fb4abe5869,

title = "Excessively increased CSF glutamate levels in GABA B -receptor antibody associated encephalitis: A case report",

abstract = "Limbic encephalitis (LE) is a rare and rather variable disease associated in part with different antibodies. The most frequent antibodies found are directed against NMDA-receptors or proteins of the voltage-gated potassium channels (LGI1, CASPR2). Additionally, in those patients suffering from LE with early and predominant seizures GABAB-receptor (GABAB-R) antibodies could be identified in serum and cerebrospinal fluid (CSF) [1]. Since blockade of GABAB-R leads to disinhibition [2], the question was raised whether the CSF profile of excitatory and inhibitory neurotransmitters is reflecting pathophysiological mechanisms of the disease. ",

author = "Andreas Moser and Henrike Hanssen and Wandinger, \{Klaus Peter\}",

year = "2018",

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day = "15",

doi = "10.1016/j.jns.2018.02.041",

language = "English",

volume = "388",

pages = "10--11",

journal = "Journal of the Neurological Sciences",

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Excessively increased CSF glutamate levels in GABA _B -receptor antibody associated encephalitis: A case report. / Moser, Andreas ; Hanssen, Henrike ; Wandinger, Klaus Peter.
In: Journal of the Neurological Sciences, Vol. 388, 15.05.2018, p. 10-11.

Research output: Journal Articles › Letters › peer-review

TY - JOUR

T1 - Excessively increased CSF glutamate levels in GABA B -receptor antibody associated encephalitis: A case report

AU - Moser, Andreas

AU - Hanssen, Henrike

AU - Wandinger, Klaus Peter

PY - 2018/5/15

Y1 - 2018/5/15

N2 - Limbic encephalitis (LE) is a rare and rather variable disease associated in part with different antibodies. The most frequent antibodies found are directed against NMDA-receptors or proteins of the voltage-gated potassium channels (LGI1, CASPR2). Additionally, in those patients suffering from LE with early and predominant seizures GABAB-receptor (GABAB-R) antibodies could be identified in serum and cerebrospinal fluid (CSF) [1]. Since blockade of GABAB-R leads to disinhibition [2], the question was raised whether the CSF profile of excitatory and inhibitory neurotransmitters is reflecting pathophysiological mechanisms of the disease.

AB - Limbic encephalitis (LE) is a rare and rather variable disease associated in part with different antibodies. The most frequent antibodies found are directed against NMDA-receptors or proteins of the voltage-gated potassium channels (LGI1, CASPR2). Additionally, in those patients suffering from LE with early and predominant seizures GABAB-receptor (GABAB-R) antibodies could be identified in serum and cerebrospinal fluid (CSF) [1]. Since blockade of GABAB-R leads to disinhibition [2], the question was raised whether the CSF profile of excitatory and inhibitory neurotransmitters is reflecting pathophysiological mechanisms of the disease.

UR - https://www.scopus.com/pages/publications/85042644701

U2 - 10.1016/j.jns.2018.02.041

DO - 10.1016/j.jns.2018.02.041

M3 - Letters

C2 - 29627000

AN - SCOPUS:85042644701

SN - 0022-510X

VL - 388

SP - 10

EP - 11

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

ER -