Limbic encephalitis (LE) is a rare and rather variable disease associated in part with different antibodies. The most frequent antibodies found are directed against NMDA-receptors or proteins of the voltage-gated potassium channels (LGI1, CASPR2). Additionally, in those patients suffering from LE with early and predominant seizures GABAB-receptor (GABAB-R) antibodies could be identified in serum and cerebrospinal fluid (CSF) . Since blockade of GABAB-R leads to disinhibition , the question was raised whether the CSF profile of excitatory and inhibitory neurotransmitters is reflecting pathophysiological mechanisms of the disease.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)