TY - JOUR
T1 - Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: Association with the functional IRAK1 196Phe/532Ser haplotype
AU - Dieudé, P.
AU - Bouaziz, M.
AU - Guedj, M.
AU - Riemekasten, G.
AU - Airò, P.
AU - Müller, M.
AU - Cusi, D.
AU - Matucci-Cerinic, M.
AU - Melchers, Inga
AU - Koenig, W.
AU - Salvi, E.
AU - Wichmann, H. E.
AU - Cuomo, G.
AU - Hachulla, E.
AU - Diot, E.
AU - Hunzelmann, N.
AU - Caramaschi, P.
AU - Mouthon, L.
AU - Riccieri, V.
AU - Distler, J.
AU - Tarner, I.
AU - Avouac, J.
AU - Meyer, O.
AU - Kahan, A.
AU - Chiocchia, G.
AU - Boileau, C.
AU - Allanore, Y.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2011/12
Y1 - 2011/12
N2 - Objective Several autoimmune disorders, including systemic sclerosis (SSc), are characterized by a strong sex bias. To date, it is not known whether genes on the sex chromosomes influence SSc susceptibility. Recently, an IRAK1 haplotype that contains the 196Phe functional variant (rs1059702), located on Xq28, was found to confer susceptibility to systemic lupus erythematosus (SLE). This study was undertaken to test for an association between SSc and the IRAK1 SLE risk haplotype. Methods We tested for an association with the IRAK1 SLE risk haplotype in a discovery set of 849 SSc patients and 625 controls. IRAK1 rs1059702 was further genotyped in a replication set, which included Caucasian women from Italy (493 SSc patients and 509 controls) and Germany (466 SSc patients and 1,083 controls). Results An association between the IRAK1 haplotype and SSc was detected in the discovery set. In both the discovery and replication sets, the rs1059702 TT genotype was found to be associated with specific SSc subsets, highlighting a potential contribution to disease severity. A meta-analysis provided evidence of an association of both the T allele and TT genotype with the overall disease, with an odds ratio (OR) of 1.20 and 95% confidence interval (95% CI) of 1.06-1.35 for the T allele (P = 0.003) and an OR of 1.49 and 95% CI of 1.06-2.10 for the TT genotype (P = 0.023). However, the most notable associations were observed with the diffuse cutaneous, anti-topoisomerase I antibody positive, and SSc-related fibrosing alveolitis subsets (OR 2.35 [95% CI 1.51-3.66], P = 1.56 × 10 -4, OR 2.84 [95% CI 1.87-4.32], P = 1.07 × 10 -6, and OR 2.09 [95% CI 1.35-3.24], P = 9.05 × 10 -4, respectively). Conclusion Our study provides the first evidence of an association between IRAK1 and SSc, demonstrating that a sex chromosome gene directly influences SSc susceptibility and its phenotypic heterogeneity.
AB - Objective Several autoimmune disorders, including systemic sclerosis (SSc), are characterized by a strong sex bias. To date, it is not known whether genes on the sex chromosomes influence SSc susceptibility. Recently, an IRAK1 haplotype that contains the 196Phe functional variant (rs1059702), located on Xq28, was found to confer susceptibility to systemic lupus erythematosus (SLE). This study was undertaken to test for an association between SSc and the IRAK1 SLE risk haplotype. Methods We tested for an association with the IRAK1 SLE risk haplotype in a discovery set of 849 SSc patients and 625 controls. IRAK1 rs1059702 was further genotyped in a replication set, which included Caucasian women from Italy (493 SSc patients and 509 controls) and Germany (466 SSc patients and 1,083 controls). Results An association between the IRAK1 haplotype and SSc was detected in the discovery set. In both the discovery and replication sets, the rs1059702 TT genotype was found to be associated with specific SSc subsets, highlighting a potential contribution to disease severity. A meta-analysis provided evidence of an association of both the T allele and TT genotype with the overall disease, with an odds ratio (OR) of 1.20 and 95% confidence interval (95% CI) of 1.06-1.35 for the T allele (P = 0.003) and an OR of 1.49 and 95% CI of 1.06-2.10 for the TT genotype (P = 0.023). However, the most notable associations were observed with the diffuse cutaneous, anti-topoisomerase I antibody positive, and SSc-related fibrosing alveolitis subsets (OR 2.35 [95% CI 1.51-3.66], P = 1.56 × 10 -4, OR 2.84 [95% CI 1.87-4.32], P = 1.07 × 10 -6, and OR 2.09 [95% CI 1.35-3.24], P = 9.05 × 10 -4, respectively). Conclusion Our study provides the first evidence of an association between IRAK1 and SSc, demonstrating that a sex chromosome gene directly influences SSc susceptibility and its phenotypic heterogeneity.
UR - http://www.scopus.com/inward/record.url?scp=82455198713&partnerID=8YFLogxK
U2 - 10.1002/art.30640
DO - 10.1002/art.30640
M3 - Journal articles
C2 - 21898345
AN - SCOPUS:82455198713
SN - 0004-3591
VL - 63
SP - 3979
EP - 3987
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 12
ER -
