Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Xinhua Yu; Saleh M. Ibrahim

doi:10.1186/ar3490

Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Xinhua Yu, Saleh M. Ibrahim^*

^*Corresponding author for this work

Department of Dermatology, Allergology and Venereology

4 Citations (Scopus)

Abstract

Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.

Original language	English
Article number	132
Journal	Arthritis Research and Therapy
Volume	13
Issue number	5
ISSN	1478-6354
DOIs	https://doi.org/10.1186/ar3490
Publication status	Published - 31.10.2011

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10.1186/ar3490

Cite this

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title = "Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis",

abstract = "Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.",

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AB - Th17 cells are thought to play a pathogenic role in various autoimmune diseases. Cytokines secreted by Th17 cells like IL-17, IL-17F and IL-22 have the capacity to mediate a massive inflammatory response. These proinflammatroy cytokines are likely to mediate the pathogenic potential of Th17 cells. Recent evidence suggests a role for Th17 cells in the breach of immune tolerance. This might shed some new light on the pathogenic role of Th17 cells in autoimmunity.

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Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Abstract

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Identification of susceptibility gene(s) controlling autoantibody production in collagen induced arthritis

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Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis

Abstract

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Identification of susceptibility gene(s) controlling autoantibody production in collagen induced arthritis

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