Event rates and risk factors for the development of diabetic ketoacidosis in adult patients with type 1 diabetes: Analysis from the DPV registry based on 46,966 patients

Hannes Kalscheuer; Jochen Seufert; Stefanie Lanzinger; Joachim Rosenbauer; Wolfram Karges; Dominik Bergis; Julia K. Mader; Stefan Zimny; Sebastian M. Schmid; Michael Hummel; Wolfgang Kerner; Reinhard W. Holl

doi:10.2337/dc18-1160

Event rates and risk factors for the development of diabetic ketoacidosis in adult patients with type 1 diabetes: Analysis from the DPV registry based on 46,966 patients

Hannes Kalscheuer^*, Jochen Seufert, Stefanie Lanzinger, Joachim Rosenbauer, Wolfram Karges, Dominik Bergis, Julia K. Mader, Stefan Zimny, Sebastian M. Schmid, Michael Hummel, Wolfgang Kerner, Reinhard W. Holl

^*Corresponding author for this work

Clinic of Internal Medicine I

32 Citations (Scopus)

Abstract

Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1DM) that results from absolute insulin deficiency and is marked by acidosis, ketosis, and hyperglycemia (1). Therefore, prevention of DKA is one goal in T1DM care, but recent data indicate increased incidence (2). For adult patients, only limited data are available on rates and risk factors for development of DKA, and this complication remains epidemiologically poorly characterized. The Diabetes Prospective Follow-up Registry (DPV) has followed patients with diabetes from 1995. Data for this study were collected from 2000 to 2016. Inclusion criteria were diagnosis of T1DM, age at diabetes onset ≥6 months, patient age at follow-up ≥18 years, and diabetes duration ≥1 year to exclude DKA at manifestation. DKA was defined as serum pH

Original language	English
Journal	Diabetes Care
Volume	42
Issue number	3
Pages (from-to)	e34-e36
Number of pages	3
ISSN	0149-5992
DOIs	https://doi.org/10.2337/dc18-1160
Publication status	Published - 01.03.2019

Funding

The authors thank An-dreas Hungele and Ramona Ranz for support and development of the DPV documentation software and Katharina Fink and Esther Bollow for DPV data management (each a clinical data manager at the University of Ulm). This study was supported by the German Diabetes Society (Deutsche Diabetes Gesellschaft) and the Federal Ministry of Education and Research (Berlin, Germany), integrated into the German Center for Diabetes Research (DZD) (FKZ 82DZD14A02). This project received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 115797 (INNODIA project).

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2337/dc18-1160

Cite this

Kalscheuer, H., Seufert, J., Lanzinger, S., Rosenbauer, J., Karges, W., Bergis, D., Mader, J. K., Zimny, S., Schmid, S. M., Hummel, M., Kerner, W., & Holl, R. W. (2019). Event rates and risk factors for the development of diabetic ketoacidosis in adult patients with type 1 diabetes: Analysis from the DPV registry based on 46,966 patients. Diabetes Care, 42(3), e34-e36. https://doi.org/10.2337/dc18-1160

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abstract = "Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1DM) that results from absolute insulin deficiency and is marked by acidosis, ketosis, and hyperglycemia (1). Therefore, prevention of DKA is one goal in T1DM care, but recent data indicate increased incidence (2). For adult patients, only limited data are available on rates and risk factors for development of DKA, and this complication remains epidemiologically poorly characterized. The Diabetes Prospective Follow-up Registry (DPV) has followed patients with diabetes from 1995. Data for this study were collected from 2000 to 2016. Inclusion criteria were diagnosis of T1DM, age at diabetes onset ≥6 months, patient age at follow-up ≥18 years, and diabetes duration ≥1 year to exclude DKA at manifestation. DKA was defined as serum pH ",

author = "Hannes Kalscheuer and Jochen Seufert and Stefanie Lanzinger and Joachim Rosenbauer and Wolfram Karges and Dominik Bergis and Mader, \{Julia K.\} and Stefan Zimny and Schmid, \{Sebastian M.\} and Michael Hummel and Wolfgang Kerner and Holl, \{Reinhard W.\}",

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Kalscheuer, H, Seufert, J, Lanzinger, S, Rosenbauer, J, Karges, W, Bergis, D, Mader, JK, Zimny, S, Schmid, SM, Hummel, M, Kerner, W & Holl, RW 2019, 'Event rates and risk factors for the development of diabetic ketoacidosis in adult patients with type 1 diabetes: Analysis from the DPV registry based on 46,966 patients', Diabetes Care, vol. 42, no. 3, pp. e34-e36. https://doi.org/10.2337/dc18-1160

Event rates and risk factors for the development of diabetic ketoacidosis in adult patients with type 1 diabetes: Analysis from the DPV registry based on 46,966 patients. / Kalscheuer, Hannes; Seufert, Jochen; Lanzinger, Stefanie et al.
In: Diabetes Care, Vol. 42, No. 3, 01.03.2019, p. e34-e36.

Research output: Journal Articles › Journal articles › Research › peer-review

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AU - Kalscheuer, Hannes

AU - Seufert, Jochen

AU - Lanzinger, Stefanie

AU - Rosenbauer, Joachim

AU - Karges, Wolfram

AU - Bergis, Dominik

AU - Mader, Julia K.

AU - Zimny, Stefan

AU - Schmid, Sebastian M.

AU - Hummel, Michael

AU - Kerner, Wolfgang

AU - Holl, Reinhard W.

PY - 2019/3/1

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Event rates and risk factors for the development of diabetic ketoacidosis in adult patients with type 1 diabetes: Analysis from the DPV registry based on 46,966 patients

Abstract

Funding

Research Areas and Centers

UN SDGs

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