Evaluation of six registration methods for the human abdomen on clinically acquired CT

Zhoubing Xu*, Christopher P. Lee, Mattias P. Heinrich, Marc Modat, Daniel Rueckert, Sebastien Ourselin, Richard G. Abramson, Bennett A. Landman

*Corresponding author for this work
6 Citations (Scopus)


Objective: This work evaluates current 3-D image registration tools on clinically acquired abdominal computed tomography (CT) scans. Methods: Thirteen abdominal organs were manually labeled on a set of 100 CT images, and the 100 labeled images (i.e., atlases) were pairwise registered based on intensity information with six registration tools (FSL, ANTS-CC, ANTS-QUICK-MI, IRTK, NIFTYREG, and DEEDS). The Dice similarity coefficient (DSC), mean surface distance, and Hausdorff distance were calculated on the registered organs individually. Permutation tests and indifference-zone ranking were performed to examine the statistical and practical significance, respectively. Results: The results suggest that DEEDS yielded the best registration performance. However, due to the overall low DSC values, and substantial portion of low-performing outliers, great care must be taken when image registration is used for local interpretation of abdominal CT. Conclusion: There is substantial room for improvement in image registration for abdominal CT. Significance: All data and source code are available so that innovations in registration can be directly compared with the current generation of tools without excessive duplication of effort.

Original languageEnglish
Article number7482649
JournalIEEE Transactions on Biomedical Engineering
Issue number8
Pages (from-to)1563-1572
Number of pages10
Publication statusPublished - 01.08.2016


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