TY - JOUR
T1 - European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology – Part I
AU - Rashid, H.
AU - Lamberts, A.
AU - Borradori, L.
AU - Alberti-Violetti, S.
AU - Barry, R. J.
AU - Caproni, M.
AU - Carey, B.
AU - Carrozzo, M.
AU - Caux, F.
AU - Cianchini, G.
AU - Corrà, A.
AU - Diercks, G. F.H.
AU - Dikkers, F. G.
AU - Di Zenzo, G.
AU - Feliciani, C.
AU - Geerling, G.
AU - Genovese, G.
AU - Hertl, M.
AU - Joly, P.
AU - Marzano, A. V.
AU - Meijer, J. M.
AU - Mercadante, V.
AU - Murrell, D. F.
AU - Ormond, M.
AU - Pas, H. H.
AU - Patsatsi, A.
AU - Prost, C.
AU - Rauz, S.
AU - van Rhijn, B. D.
AU - Roth, M.
AU - Schmidt, E.
AU - Setterfield, J.
AU - Zambruno, G.
AU - Zillikens, D.
AU - Horváth, B.
N1 - Publisher Copyright:
© 2021 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology
PY - 2021/9
Y1 - 2021/9
N2 - This guideline on mucous membrane pemphigoid (MMP) has been elaborated by the Task Force for Autoimmune Blistering Diseases of the European Academy of Dermatology and Venereology (EADV) with a contribution of physicians from all relevant disciplines and patient organizations. It is a S3 consensus-based guideline encompassing a systematic review of the literature until June 2019 in the MEDLINE and EMBASE databases. This first part covers methodology, the clinical definition of MMP, epidemiology, MMP subtypes, immunopathological characteristics, disease assessment and outcome scores. MMP describes a group of autoimmune skin and mucous membrane blistering diseases, characterized by a chronic course and by predominant involvement of the mucous membranes, such as the oral, ocular, nasal, nasopharyngeal, anogenital, laryngeal and oesophageal mucosa. MMP patients may present with mono- or multisite involvement. Patients’ autoantibodies have been shown to be predominantly directed against BP180 (also called BPAG2, type XVII collagen), BP230, laminin 332 and type VII collagen, components of junctional adhesion complexes promoting epithelial stromal attachment in stratified epithelia. Various disease assessment scores are available, including the Mucous Membrane Pemphigoid Disease Area Index (MMPDAI), the Autoimmune Bullous Skin disorder Intensity Score (ABSIS), the ‘Cicatrising Conjunctivitis Assessment Tool’ and the Oral Disease Severity Score (ODSS). Patient-reported outcome measurements (PROMs), including DLQI, ABQOL and TABQOL, can be used for assessment of quality of life to evaluate the effectiveness of therapeutic interventions and monitor disease course.
AB - This guideline on mucous membrane pemphigoid (MMP) has been elaborated by the Task Force for Autoimmune Blistering Diseases of the European Academy of Dermatology and Venereology (EADV) with a contribution of physicians from all relevant disciplines and patient organizations. It is a S3 consensus-based guideline encompassing a systematic review of the literature until June 2019 in the MEDLINE and EMBASE databases. This first part covers methodology, the clinical definition of MMP, epidemiology, MMP subtypes, immunopathological characteristics, disease assessment and outcome scores. MMP describes a group of autoimmune skin and mucous membrane blistering diseases, characterized by a chronic course and by predominant involvement of the mucous membranes, such as the oral, ocular, nasal, nasopharyngeal, anogenital, laryngeal and oesophageal mucosa. MMP patients may present with mono- or multisite involvement. Patients’ autoantibodies have been shown to be predominantly directed against BP180 (also called BPAG2, type XVII collagen), BP230, laminin 332 and type VII collagen, components of junctional adhesion complexes promoting epithelial stromal attachment in stratified epithelia. Various disease assessment scores are available, including the Mucous Membrane Pemphigoid Disease Area Index (MMPDAI), the Autoimmune Bullous Skin disorder Intensity Score (ABSIS), the ‘Cicatrising Conjunctivitis Assessment Tool’ and the Oral Disease Severity Score (ODSS). Patient-reported outcome measurements (PROMs), including DLQI, ABQOL and TABQOL, can be used for assessment of quality of life to evaluate the effectiveness of therapeutic interventions and monitor disease course.
UR - http://www.scopus.com/inward/record.url?scp=85109954082&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/07787bdc-d41a-3687-a3ba-38286e3d6e61/
U2 - 10.1111/jdv.17397
DO - 10.1111/jdv.17397
M3 - Journal articles
AN - SCOPUS:85109954082
SN - 0926-9959
VL - 35
SP - 1750
EP - 1764
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 9
ER -