European Association of Urology Guidelines for Clear Cell Renal Cancers That Are Resistant to Vascular Endothelial Growth Factor Receptor–Targeted Therapy

Thomas Powles*, Michael Staehler, Börje Ljungberg, Karim Bensalah, Steven E. Canfield, Saeed Dabestani, Rachel H. Giles, Fabian Hofmann, Milan Hora, Markus A. Kuczyk, Thomas Lam, Lorenzo Marconi, Axel S. Merseburger, Alessandro Volpe, Axel Bex

*Corresponding author for this work
38 Citations (Scopus)

Abstract

The European Association of Urology renal cancer guidelines panel recommends nivolumab and cabozantinib over the previous standard of care in patients who have failed one or more lines of vascular endothelial growth factor–targeted therapy. New data have recently become available showing a survival benefit for cabozantinib.

Original languageEnglish
JournalEuropean Urology
Volume70
Issue number5
Pages (from-to)705-706
Number of pages2
ISSN0302-2838
DOIs
Publication statusPublished - 11.2016

Funding

Conflicts of interest: T. Powles is a company consultant for Novartis, Pfizer, GSK; has received company speaker honoraria from Novartis, Pfizer, GSK, Genentech; performed trial participation for GSK, Pfizer, BMS, Genentech, Genetech; and received grants/research support from GSK, Pfizer, and Novartis. A. Bex has received company speaker honoraria from Pfizer; performed trial participation for Pfizer Europe; participated on advisory boards for GSK and Novartis; is a company consultant for Pfizer and Novartis; and received grants/research support from Pfizer. M. Staehler is a company consultant for Pfizer, Novartis, GSK, Roche, Astellas, Bayer; has received company speaker honoraria from Pfizer, Novartis, GSK, Roche, Astellas, Bayer, Aveo; has performed trial participation for Pfizer, Novartis, GSK, Roche, Bayer, Aveo, Wilex, Immatics; has received fellowships and travel grants from Pfizer, Novartis, GSK, Roche, Bayer; has received grants/research support from Pfizer, Novartis, GSK, Roche, Bayer, and Aveo. B. Ljungberg has received company speaker honoraria from GlaxoSmithKline, Roche, Pfizer, Novartis; performed trial participation for GlaxoSmithKline, Medivation, Pfizer, Janssen R&D, Inc.; and been on advisory boards for Pfizer and GSK. K. Bensalah has received grants/research support from Pfizer and honoraria or consultation fees from Intuitive Surgical. S. Canfield has received company speaker honoraria from Amgen, Genomic Health, Algeta, and Bayer. M. Hora has received company speaker honoraria from Covidien, Olympus, Janssen, Astellas; performed trial participation for Janssen; and received grants/research support from Ipsen. M.A. Kuczyk is a stock shareholder of Bayer Healthcare, Astellas, Storz, Pfizer, Wyeth, Novartis; is a company consultant for Karl Storz, Coloplast, AstraZeneca, Astellas, Storz, Hexal AG; has received company speaker honoraria from Pfizer, Astellas, Bayer, GSK, Pierre Fabre, Janssen Cilag, Hexal; performed trial participation for the Protect Study, Millenium Study C21004, Millenium Study C21005, Astellas, Ipsen, Janssen; and received grants/research support from Wyeth and Pfizer. T. Lam is a company consultant for and has received company speaker honoraria from Pfizer, GSK, Astellas, and Ipsen. A. Merseburger is a company consultant for Ipsen Pharma, Bayer, Astellas, Janssen Cilag, Novartis, and Pfizer; has received company speaker honoraria from Ipsen Pharma, Wyeth, Astellas, Novartis, Pfizer, SEP; performed trial participation for AstraZeneca, Bayer, Pfizer, TEVA, Novartis, Astellas; received grants/research support from Wyeth; and participated in a company-sponsored speakers bureau for TEVA, Janssen, Pfizer, Astellas, Ferring, and Novartis. S. Dabestani, R.H. Giles, F. Hofmann, L. Marconi, and A. Volpe have nothing to disclose.

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)

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