Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression

Dirk Rades; Antonio J. Conde-Moreno; Jon Cacicedo; Barbara Szegedin; Steven E. Schild

Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression

Dirk Rades, Antonio J. Conde-Moreno, Jon Cacicedo, Barbara Szegedin, Steven E. Schild

Department of Radiotherapy

Abstract

AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.

PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.

RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001).

CONCLUSION: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.

Original language	English
Journal	Anticancer Research
Volume	36
Issue number	1
Pages (from-to)	409-413
Number of pages	5
ISSN	0250-7005
Publication status	Published - 01.01.2016

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@article{bc3360c19d7242acbaaaf8e8d070c691,

title = "Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression",

abstract = "AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8\%, 30\%, 69\% and 100\%, respectively (p<0.001).CONCLUSION: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.",

author = "Dirk Rades and Conde-Moreno, \{Antonio J.\} and Jon Cacicedo and Barbara Szegedin and Schild, \{Steven E.\}",

note = "Publisher Copyright: Copyright{\textcopyright} 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. Copyright: This record is sourced from MEDLINE{\textregistered}/PubMed{\textregistered}, a database of the U.S. National Library of Medicine",

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T1 - Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression

AU - Rades, Dirk

AU - Conde-Moreno, Antonio J.

AU - Cacicedo, Jon

AU - Szegedin, Barbara

AU - Schild, Steven E.

N1 - Publisher Copyright: Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2016/1/1

Y1 - 2016/1/1

N2 - AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001).CONCLUSION: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.

AB - AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001).CONCLUSION: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.

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M3 - Journal articles

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AN - SCOPUS:84973409446

SN - 0250-7005

VL - 36

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Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression

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