Abstract
AIM: To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma.
PATIENTS AND METHODS: In 71 elderly patients, 10 factors were analyzed. Predictive scores were generated based on 6-month survival rates.
RESULTS: Longer interval from renal cell carcinoma diagnosis to MSCC (p=0.019), lack of visceral metastases (p<0.001), slower progression of motor deficits (p<0.001), ambulation (p<0.001) and better performance status (p=0.002) were positive predictors. On multivariate analysis, interval from renal cell carcinoma diagnosis to MSCC (p=0.022), visceral metastases (p<0.001), time to developing motor dysfunction (p=0.041), gait function (p=0.002) and performance status (p=0.017) remained significant. Predictive scores were 17 to 36 points. Four groups were created: 17-23, 24-26, 27-29 and 30-36 points. Six-month survival rates were 8%, 30%, 69% and 100%, respectively (p<0.001).
CONCLUSION: This tool improves estimation of survival and personalized treatment options in elderly patients with MSCC from renal cell carcinoma.
| Original language | English |
|---|---|
| Journal | Anticancer Research |
| Volume | 36 |
| Issue number | 1 |
| Pages (from-to) | 409-413 |
| Number of pages | 5 |
| ISSN | 0250-7005 |
| Publication status | Published - 01.01.2016 |
