Estimating the stopping power distribution during proton therapy: A proof of concept

V. Ferrero* (Shared First Author), Julius Friedemann Werner (Shared First Author), Piergiorgio Cerello, Elisa Fiorina, Anna Vignati, F. Pennazio (Shared Last Author), Magdalena Rafecas (Shared Last Author)

*Corresponding author for this work


Objective: We introduce a new treatment verification technique to estimate the primary particle’s stopping power from prompt gamma timing measurements in proton therapy.

Approach: The starting point is the Spatio-temporal Emission Recostruction technique, which provides the time-depth distribution of the emitted prompt photons with a multiple Prompt-Gamma Timing detector setup based on Lanthanum Bromide crystals. A dedicated formalism based on an analytical approximation of the stopping power is developed to obtain the desired information. Its performance is evaluated in a proof of concept configuration via Monte Carlo simulations of monochromatic proton beams impinging on a homogeneous PMMA phantom.

Main Results: Results indicate stopping power estimations as good as 3.8% with respect to NIST values, and range estimations within 0.3 cm (standard deviation), when considering 250 ps FWHM timing resolution.

Significance: The current study shows, for the first time, the feasibility of evaluating the stopping power of primary beams with a technique that can be performed in-vivo, opening up new possibilities in the field of treatment verification and therapy optimization.
Translated title of the contributionAbschätzung der Bremsvermögensverteilung während der Partikeltherapie: eine Machbarkeitsstudie
Original languageEnglish
Article number971767
JournalFrontiers in Physics
Publication statusPublished - 28.09.2022

Research Areas and Centers

  • Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

  • 205-32 Medical Physics, Biomedical Engineering


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