Estimating disequilibrium coefficients

Maren Vens; Andreas Ziegler

doi:10.1007/978-1-4939-7274-6_7

Estimating disequilibrium coefficients

Maren Vens^*, Andreas Ziegler

^*Corresponding author for this work

Institute of Medical Biometry and Statistics

7 Citations (Scopus)

Abstract

Gametic phase disequilibrium is the nonrandom association of alleles within gametes. Linkage disequilibrium (LD) describes the special case of deviation from independence between alleles at two linked genetic loci. Estimation of allelic LD requires knowledge of haplotypes. Genotype-based LD measures dispense with the haplotype estimation step and avoid bias in LD estimation. In this chapter, the most important measures for allelic and genotypic LD are introduced. The use of software packages for LD estimation is illustrated.

Original language	English
Title of host publication	Methods in Molecular Biology
Number of pages	16
Publisher	Humana Press Inc.
Publication date	2017
Pages	117-132
DOIs	https://doi.org/10.1007/978-1-4939-7274-6_7
Publication status	Published - 2017

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10.1007/978-1-4939-7274-6_7

Cite this

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AB - Gametic phase disequilibrium is the nonrandom association of alleles within gametes. Linkage disequilibrium (LD) describes the special case of deviation from independence between alleles at two linked genetic loci. Estimation of allelic LD requires knowledge of haplotypes. Genotype-based LD measures dispense with the haplotype estimation step and avoid bias in LD estimation. In this chapter, the most important measures for allelic and genotypic LD are introduced. The use of software packages for LD estimation is illustrated.

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BT - Methods in Molecular Biology

PB - Humana Press Inc.

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Estimating disequilibrium coefficients

Abstract

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