Erythropoietin research, 80 years after the initial studies by Carnot and Deflandre

W. Jelkmann

doi:10.1016/0034-5687(86)90093-9

Erythropoietin research, 80 years after the initial studies by Carnot and Deflandre

W. Jelkmann^*

^*Corresponding author for this work

Institute of Physiology

19 Citations (Scopus)

Abstract

The discovery and present state of knowledge of the specific hormonal mechanism controlling erythropoiesis are briefly reviewed. 80 year ago, Carnot and Deflandre postulated the existence of a humoral erythropoietic factor ('hémopoïétine') produced in response to anemia. The general approval of this concept required almost 50 years, when the factor was recognized to be a glycoprotein hormone and termed 'erythropoietin'. Very recently, human erythropoietin has been purified and its amino acid sequence been identified. The hormone is mainly of renal origins. Its production is stimulated by tissue hypoxia of different causes. The mechanism of O₂ sensing and the exact site of erythropoietin synthesis in the kidney still remain to be clarified.

Original language	English
Journal	Respiration Physiology
Volume	63
Issue number	3
Pages (from-to)	257-266
Number of pages	10
ISSN	0034-5687
DOIs	https://doi.org/10.1016/0034-5687(86)90093-9
Publication status	Published - 03.1986

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1016/0034-5687(86)90093-9

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abstract = "The discovery and present state of knowledge of the specific hormonal mechanism controlling erythropoiesis are briefly reviewed. 80 year ago, Carnot and Deflandre postulated the existence of a humoral erythropoietic factor ('h{\'e}mopo{\"i}{\'e}tine') produced in response to anemia. The general approval of this concept required almost 50 years, when the factor was recognized to be a glycoprotein hormone and termed 'erythropoietin'. Very recently, human erythropoietin has been purified and its amino acid sequence been identified. The hormone is mainly of renal origins. Its production is stimulated by tissue hypoxia of different causes. The mechanism of O2 sensing and the exact site of erythropoietin synthesis in the kidney still remain to be clarified.",

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AB - The discovery and present state of knowledge of the specific hormonal mechanism controlling erythropoiesis are briefly reviewed. 80 year ago, Carnot and Deflandre postulated the existence of a humoral erythropoietic factor ('hémopoïétine') produced in response to anemia. The general approval of this concept required almost 50 years, when the factor was recognized to be a glycoprotein hormone and termed 'erythropoietin'. Very recently, human erythropoietin has been purified and its amino acid sequence been identified. The hormone is mainly of renal origins. Its production is stimulated by tissue hypoxia of different causes. The mechanism of O2 sensing and the exact site of erythropoietin synthesis in the kidney still remain to be clarified.

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Erythropoietin research, 80 years after the initial studies by Carnot and Deflandre

Abstract

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