Erfolgreiches Bündel von Präventionsmaßnahmen bei hoher CDAD-Inzidenz in einem Universitätsklinikum

Translated title of the contribution: Successful bundle of prevention measures against a high CDAD incidence at a university hospital

Frauke Mattner*, Ingo Winterfeld, Johannes Knobloch, Werner Solbach

*Corresponding author for this work
    1 Citation (Scopus)


    Background: Recently, dramatically increasing nosocomial C. difficile associated disease (CDAD) infection rates were reported from many hospitals. Consequently the question of "how to prevent" is of utmost importance. Here, we show the effectiveness of a hospital-wide intervention program. Methods: Between May 2007 and April 2008 the following infection control measures were introduced: analysis of the epidemiological situation (2000-2007), use of disinfectants effective against C. difficile and increase of frequency of environmental cleaning of private rooms, a prospective surveillance for CDAD and an education program for medical staff. Sensitivity values of three different culture media were determined analysing 256 consecutive stool samples. Results: Between 2000 and 2006 a significant increase of CDAD cases occurred. No further increase occurred in 2007. Among eleven different wards, which were identified to habour significantly more cases than the remainders, eight of them significantly reduced nosocomial CDAD acquisition during the intervention program. Three different culture media yielded a sensitivity for the detection of C. difficile In 256 stool samples of 70%, 74 %, and 89 %, respectively. The addition of the most sensitive culture medium to the microbial diagnostic doubled the sensitivity of detection of Toxin A or B producing C. difficiles stool samples. Conclusion: Even after increasing the sensitivity for detection of C. difficile by 100%, hospital-wide a further increase of CDAD cases was stopped. Our data show the effectiveness of a bundle of inventions for the infection control of nosocomial CDAD.

    Translated title of the contributionSuccessful bundle of prevention measures against a high CDAD incidence at a university hospital
    Original languageGerman
    JournalHygiene + Medizin
    Issue number9
    Pages (from-to)346-352
    Number of pages7
    Publication statusPublished - 01.09.2008

    Research Areas and Centers

    • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


    Dive into the research topics of 'Successful bundle of prevention measures against a high CDAD incidence at a university hospital'. Together they form a unique fingerprint.

    Cite this