A 25-year-old patient was admitted urgently due to mixed amitriptyline/quetiapine intoxication at a potentially lethal dose. Alongside severe anticholinergic toxidrome, she presented with antiadrenergic and quinidin-like cardiotoxic findings, including ventricular tachycardia. In the present case, arrhythmia and circulatory shock responded neither to alkalization and elevated sodium levels after infusion of sodium bicarbonate, nor to any other established therapies. Following the lipid rescue paradigm, bolus infusion of a 20% lipid emulsion led to rapid stabilization and continued reversal of all intoxication features.
|Translated title of the contribution||Successful lipid rescue therapy in a case of severe amitriptyline/quetiapine intoxication|
|Journal||Medizinische Klinik - Intensivmedizin und Notfallmedizin|
|Number of pages||4|
|Publication status||Published - 01.05.2018|
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)