ER-to-Golgi transport: COP I and COP II function

Rainer Duden

doi:10.1080/0968768031000122548

ER-to-Golgi transport: COP I and COP II function

Rainer Duden^*

^*Corresponding author for this work

Institute of Biology

147 Citations (Scopus)

Abstract

COP I and COP II coat proteins direct protein and membrane trafficking in between early compartments of the secretory pathway in eukaryotic cells. These coat proteins perform the dual, essential tasks of selecting appropriate cargo proteins and deforming the lipid bilayer of appropriate donor membranes into buds and vesicles. COP II proteins are required for selective export of newly synthesized proteins from the endoplasmic reticulum (ER). COP I proteins mediate a retrograde transport pathway that selectively recycles proteins from the cis-Golgi complex to the ER. Additionally, COP I coat proteins have complex functions in intra-Golgi trafficking and in maintaining the normal structure of the mammalian interphase Golgi complex.

Original language	English
Journal	Molecular Membrane Biology
Volume	20
Issue number	3
Pages (from-to)	197-207
Number of pages	11
ISSN	0968-7688
DOIs	https://doi.org/10.1080/0968768031000122548
Publication status	Published - 07.2003

Funding

I wish to apologize to all authors who have contributed to our knowledge of COP I and COP II function whose original work could not be cited due to space constraints. R.D. is the recipient of a Wellcome Trust Senior Fellowship in Basic Biomedical Sciences (Grant No. 047578).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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Cite this

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abstract = "COP I and COP II coat proteins direct protein and membrane trafficking in between early compartments of the secretory pathway in eukaryotic cells. These coat proteins perform the dual, essential tasks of selecting appropriate cargo proteins and deforming the lipid bilayer of appropriate donor membranes into buds and vesicles. COP II proteins are required for selective export of newly synthesized proteins from the endoplasmic reticulum (ER). COP I proteins mediate a retrograde transport pathway that selectively recycles proteins from the cis-Golgi complex to the ER. Additionally, COP I coat proteins have complex functions in intra-Golgi trafficking and in maintaining the normal structure of the mammalian interphase Golgi complex.",

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ER -

ER-to-Golgi transport: COP I and COP II function

Abstract

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