TY - JOUR
T1 - ER-to-Golgi transport: COP I and COP II function
AU - Duden, Rainer
N1 - Funding Information:
I wish to apologize to all authors who have contributed to our knowledge of COP I and COP II function whose original work could not be cited due to space constraints. R.D. is the recipient of a Wellcome Trust Senior Fellowship in Basic Biomedical Sciences (Grant No. 047578).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/7
Y1 - 2003/7
N2 - COP I and COP II coat proteins direct protein and membrane trafficking in between early compartments of the secretory pathway in eukaryotic cells. These coat proteins perform the dual, essential tasks of selecting appropriate cargo proteins and deforming the lipid bilayer of appropriate donor membranes into buds and vesicles. COP II proteins are required for selective export of newly synthesized proteins from the endoplasmic reticulum (ER). COP I proteins mediate a retrograde transport pathway that selectively recycles proteins from the cis-Golgi complex to the ER. Additionally, COP I coat proteins have complex functions in intra-Golgi trafficking and in maintaining the normal structure of the mammalian interphase Golgi complex.
AB - COP I and COP II coat proteins direct protein and membrane trafficking in between early compartments of the secretory pathway in eukaryotic cells. These coat proteins perform the dual, essential tasks of selecting appropriate cargo proteins and deforming the lipid bilayer of appropriate donor membranes into buds and vesicles. COP II proteins are required for selective export of newly synthesized proteins from the endoplasmic reticulum (ER). COP I proteins mediate a retrograde transport pathway that selectively recycles proteins from the cis-Golgi complex to the ER. Additionally, COP I coat proteins have complex functions in intra-Golgi trafficking and in maintaining the normal structure of the mammalian interphase Golgi complex.
UR - http://www.scopus.com/inward/record.url?scp=0038726917&partnerID=8YFLogxK
U2 - 10.1080/0968768031000122548
DO - 10.1080/0968768031000122548
M3 - Scientific review articles
C2 - 12893528
AN - SCOPUS:0038726917
SN - 0968-7688
VL - 20
SP - 197
EP - 207
JO - Molecular Membrane Biology
JF - Molecular Membrane Biology
IS - 3
ER -
