Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression

Sebastian Marwitz; Lena Heinbockel; Swetlana Scheufele; Dörte Nitschkowski; Christian Kugler; Sven Perner; Martin Reck; Ole Ammerpohl; Torsten Goldmann

doi:10.1186/s13148-017-0423-6

Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression

Sebastian Marwitz, Lena Heinbockel^*, Swetlana Scheufele, Dörte Nitschkowski, Christian Kugler, Sven Perner, Martin Reck, Ole Ammerpohl, Torsten Goldmann

^*Corresponding author for this work

Institute of Pathology

11 Citations (Scopus)

Abstract

Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased transcription of the VGF gene within the tumors, which then leads to an increased expression of the protein, facilitating epithelial-mesenchymal transition, and the resistance to kinase inhibitors. These results should be taken into account in the design of novel therapeutic and diagnostic approaches.

Original language	English
Article number	123
Journal	Clinical Epigenetics
Volume	9
Issue number	1
ISSN	1868-7075
DOIs	https://doi.org/10.1186/s13148-017-0423-6
Publication status	Published - 28.11.2017

Funding

This work was funded by the German Center for Lung Research (DZL; 82DZL001A5). Human tissues were provided by the BioMaterialBank North, which is funded in part by the Airway Research Center North (ARCN), member of the German Center for Lung Research (DZL), and is member of PopGen 2.0 Network (P2N), which is supported by a grant from the German Ministry for Education and Research (01EY1103).

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abstract = "Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased transcription of the VGF gene within the tumors, which then leads to an increased expression of the protein, facilitating epithelial-mesenchymal transition, and the resistance to kinase inhibitors. These results should be taken into account in the design of novel therapeutic and diagnostic approaches.",

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T1 - Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression

AU - Marwitz, Sebastian

AU - Heinbockel, Lena

AU - Scheufele, Swetlana

AU - Nitschkowski, Dörte

AU - Kugler, Christian

AU - Perner, Sven

AU - Reck, Martin

AU - Ammerpohl, Ole

AU - Goldmann, Torsten

PY - 2017/11/28

Y1 - 2017/11/28

N2 - Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased transcription of the VGF gene within the tumors, which then leads to an increased expression of the protein, facilitating epithelial-mesenchymal transition, and the resistance to kinase inhibitors. These results should be taken into account in the design of novel therapeutic and diagnostic approaches.

AB - Hwang et al. recently showed that VGF substantially contributes to the resistance of human lung cancer cells towards epidermal growth factor receptor kinase inhibitors. This was further linked to enhanced epithelial-mesenchymal transition. Here, we demonstrate that VGF is epigenetically modified in non-small cell lung cancer tissues compared to corresponding tumor-free lung tissues from the same donors by using methylome bead chip analyses. These epigenetic modifications trigger an increased transcription of the VGF gene within the tumors, which then leads to an increased expression of the protein, facilitating epithelial-mesenchymal transition, and the resistance to kinase inhibitors. These results should be taken into account in the design of novel therapeutic and diagnostic approaches.

UR - https://www.scopus.com/pages/publications/85035126481

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DO - 10.1186/s13148-017-0423-6

M3 - Letters

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AN - SCOPUS:85035126481

SN - 1868-7075

VL - 9

JO - Clinical Epigenetics

JF - Clinical Epigenetics

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ER -

Epigenetic modifications of the VGF gene in human non-small cell lung cancer tissues pave the way towards enhanced expression

Abstract

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