Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

Matthieu Groh; Christian Pagnoux; Chiara Baldini; Elisabeth Bel; Paolo Bottero; Vincent Cottin; Klaus Dalhoff; Bertrand Dunogué; Wolfgang Gross; Julia Holle; Marc Humbert; David Jayne; J. Charles Jennette; Romain Lazor; Alfred Mahr; Peter A. Merkel; Luc Mouthon; Renato Alberto Sinico; Ulrich Specks; Augusto Vaglio; Michael E. Wechsler; Jean François Cordier; Loïc Guillevin

doi:10.1016/j.ejim.2015.04.022

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

Matthieu Groh, Christian Pagnoux, Chiara Baldini, Elisabeth Bel, Paolo Bottero, Vincent Cottin, Klaus Dalhoff, Bertrand Dunogué, Wolfgang Gross, Julia Holle, Marc Humbert, David Jayne, J. Charles Jennette, Romain Lazor, Alfred Mahr, Peter A. Merkel, Luc Mouthon, Renato Alberto Sinico, Ulrich Specks, Augusto VaglioMichael E. Wechsler, Jean François Cordier, Loïc Guillevin^*

^*Corresponding author for this work

393 Citations (Scopus)

Abstract

Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.

Original language	English
Journal	European Journal of Internal Medicine
Volume	26
Issue number	7
Pages (from-to)	545-553
Number of pages	9
ISSN	0953-6205
DOIs	https://doi.org/10.1016/j.ejim.2015.04.022
Publication status	Published - 01.09.2015

Funding

David Jayne: research grants from Genzyme and Roche/Genentech; consultancy for Aurinia, Biogen, Chemocentryx, GSK, Lilly and Medimmune, Merck Serono and Roche/Genentech. Peter Merkel: research grants from Bristol-Myers Squibb, Celgene, Genentech/Roche and GSK; consulting fees from Actelion, GSK and Sanofi. Loïc Guillevin: Member of the Advisory Board that designed an EGPA mepolizumab trial; member of the Scientific Council of the AIR registry, funded by Roche Laboratory; lecture fees paid by LFB, Roche Pharma and CSL Behring; Roche Laboratory partially provided rituximab for the MAINRITSAN trial (National PHRC No. 2008-002846-51) comparing rituximab vs. azathioprine as maintenance therapy for ANCA-associated vasculitides.

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ejim.2015.04.022

Cite this

Groh, M., Pagnoux, C., Baldini, C., Bel, E., Bottero, P., Cottin, V., Dalhoff, K., Dunogué, B., Gross, W., Holle, J., Humbert, M., Jayne, D., Jennette, J. C., Lazor, R., Mahr, A., Merkel, P. A., Mouthon, L., Sinico, R. A., Specks, U., ... Guillevin, L. (2015). Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. European Journal of Internal Medicine, 26(7), 545-553. https://doi.org/10.1016/j.ejim.2015.04.022

@article{74084008692c445380f407d74554cc4e,

title = "Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management",

abstract = "Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.",

author = "Matthieu Groh and Christian Pagnoux and Chiara Baldini and Elisabeth Bel and Paolo Bottero and Vincent Cottin and Klaus Dalhoff and Bertrand Dunogu{\'e} and Wolfgang Gross and Julia Holle and Marc Humbert and David Jayne and Jennette, \{J. Charles\} and Romain Lazor and Alfred Mahr and Merkel, \{Peter A.\} and Luc Mouthon and Sinico, \{Renato Alberto\} and Ulrich Specks and Augusto Vaglio and Wechsler, \{Michael E.\} and Cordier, \{Jean Fran{\c c}ois\} and Lo{\"i}c Guillevin",

note = "Funding Information: David Jayne: research grants from Genzyme and Roche/Genentech; consultancy for Aurinia, Biogen, Chemocentryx, GSK, Lilly and Medimmune, Merck Serono and Roche/Genentech. Funding Information: Peter Merkel: research grants from Bristol-Myers Squibb, Celgene, Genentech/Roche and GSK; consulting fees from Actelion, GSK and Sanofi. Funding Information: Lo{\"i}c Guillevin: Member of the Advisory Board that designed an EGPA mepolizumab trial; member of the Scientific Council of the AIR registry, funded by Roche Laboratory; lecture fees paid by LFB, Roche Pharma and CSL Behring; Roche Laboratory partially provided rituximab for the MAINRITSAN trial (National PHRC No. 2008-002846-51) comparing rituximab vs. azathioprine as maintenance therapy for ANCA-associated vasculitides. Publisher Copyright: {\textcopyright} 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

year = "2015",

month = sep,

day = "1",

doi = "10.1016/j.ejim.2015.04.022",

language = "English",

volume = "26",

pages = "545--553",

journal = "European Journal of Internal Medicine",

issn = "0953-6205",

publisher = "Elsevier B.V.",

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Groh, M, Pagnoux, C, Baldini, C, Bel, E, Bottero, P, Cottin, V, Dalhoff, K, Dunogué, B, Gross, W, Holle, J, Humbert, M, Jayne, D, Jennette, JC, Lazor, R, Mahr, A, Merkel, PA, Mouthon, L, Sinico, RA, Specks, U, Vaglio, A, Wechsler, ME, Cordier, JF & Guillevin, L 2015, 'Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management', European Journal of Internal Medicine, vol. 26, no. 7, pp. 545-553. https://doi.org/10.1016/j.ejim.2015.04.022

TY - JOUR

T1 - Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

AU - Groh, Matthieu

AU - Pagnoux, Christian

AU - Baldini, Chiara

AU - Bel, Elisabeth

AU - Bottero, Paolo

AU - Cottin, Vincent

AU - Dalhoff, Klaus

AU - Dunogué, Bertrand

AU - Gross, Wolfgang

AU - Holle, Julia

AU - Humbert, Marc

AU - Jayne, David

AU - Jennette, J. Charles

AU - Lazor, Romain

AU - Mahr, Alfred

AU - Merkel, Peter A.

AU - Mouthon, Luc

AU - Sinico, Renato Alberto

AU - Specks, Ulrich

AU - Vaglio, Augusto

AU - Wechsler, Michael E.

AU - Cordier, Jean François

AU - Guillevin, Loïc

N1 - Funding Information: David Jayne: research grants from Genzyme and Roche/Genentech; consultancy for Aurinia, Biogen, Chemocentryx, GSK, Lilly and Medimmune, Merck Serono and Roche/Genentech. Funding Information: Peter Merkel: research grants from Bristol-Myers Squibb, Celgene, Genentech/Roche and GSK; consulting fees from Actelion, GSK and Sanofi. Funding Information: Loïc Guillevin: Member of the Advisory Board that designed an EGPA mepolizumab trial; member of the Scientific Council of the AIR registry, funded by Roche Laboratory; lecture fees paid by LFB, Roche Pharma and CSL Behring; Roche Laboratory partially provided rituximab for the MAINRITSAN trial (National PHRC No. 2008-002846-51) comparing rituximab vs. azathioprine as maintenance therapy for ANCA-associated vasculitides. Publisher Copyright: © 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.

AB - Objective To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Methods The EGPA Consensus Task Force experts comprised 8 pulmonologists, 6 internists, 4 rheumatologists, 3 nephrologists, 1 pathologist and 1 allergist from 5 European countries and the USA. Using a modified Delphi process, a list of 40 questions was elaborated by 2 members and sent to all participants prior to the meeting. Concurrently, an extensive literature search was undertaken with publications assigned with a level of evidence according to accepted criteria. Drafts of the recommendations were circulated for review to all members until final consensus was reached. Results Twenty-two recommendations concerning the diagnosis, initial evaluation, treatment and monitoring of EGPA patients were established. The relevant published information on EGPA, antineutrophil-cytoplasm antibody-associated vasculitides, hypereosinophilic syndromes and eosinophilic asthma supporting these recommendations was also reviewed. Discussion These recommendations aim to give physicians tools for effective and individual management of EGPA patients, and to provide guidance for further targeted research.

UR - https://www.scopus.com/pages/publications/84941599615

U2 - 10.1016/j.ejim.2015.04.022

DO - 10.1016/j.ejim.2015.04.022

M3 - Journal articles

C2 - 25971154

AN - SCOPUS:84941599615

SN - 0953-6205

VL - 26

SP - 545

EP - 553

JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

IS - 7

ER -

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management

Abstract

Funding

Research Areas and Centers

UN SDGs

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