TY - JOUR
T1 - Enhancement in dopamine reduces generous behaviour in women
AU - Artigas, Sergio Oroz
AU - Liu, Lu
AU - Strang, Sabrina
AU - Burrasch, Caroline
AU - Hermsteiner, Astrid
AU - Münte, Thomas F.
AU - Park, Soyoung Q.
N1 - Funding Information:
S.Q.P. was supported by the German Research Foundation Grants PA 2682/2-1, PA 2682/1-2, FOR 2698/1 (TP3), INST 392/125-1 (C07), and SFB TR 134 (C07). Both S.Q.P. and L.L. were supported by a grant from the German Ministry of Education and Research (BMBF) and the State of Brandenburg (DZD grant FKZ 82DZD00302)
Publisher Copyright:
© 2019 Oroz Artigas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Generosity is a human behavior common in social contexts. However, humans are not equally generous to everyone alike. Instead, generosity decreases as a function of social distance, an effect called social discounting. Studies show that such social discounting effect depends on diverse factors including personality traits, cultures, stress or hormonal levels. Recently, the importance of the neurotransmitter dopamine in regulating social interactions has been highlighted. However, it remains unclear how exactly dopamine agonist administration modulates generous behavior as a function of social discounting. Here, we investigate the causal effect of dopamine agonist administration on social discounting in a pharmacological intervention study. We employ a randomized, double-blind, within-subject design to investigate the impact of the D2/D3 receptor agonist pramipexole on social discounting by keeping gender constant. We apply hyperbolic social discount model to the data and provide evidence that women under pramipexole become less generous in general, especially towards close others. Our results highlight the crucial role of dopamine in social decision making.
AB - Generosity is a human behavior common in social contexts. However, humans are not equally generous to everyone alike. Instead, generosity decreases as a function of social distance, an effect called social discounting. Studies show that such social discounting effect depends on diverse factors including personality traits, cultures, stress or hormonal levels. Recently, the importance of the neurotransmitter dopamine in regulating social interactions has been highlighted. However, it remains unclear how exactly dopamine agonist administration modulates generous behavior as a function of social discounting. Here, we investigate the causal effect of dopamine agonist administration on social discounting in a pharmacological intervention study. We employ a randomized, double-blind, within-subject design to investigate the impact of the D2/D3 receptor agonist pramipexole on social discounting by keeping gender constant. We apply hyperbolic social discount model to the data and provide evidence that women under pramipexole become less generous in general, especially towards close others. Our results highlight the crucial role of dopamine in social decision making.
UR - https://www.scopus.com/pages/publications/85077393689
U2 - 10.1371/journal.pone.0226893
DO - 10.1371/journal.pone.0226893
M3 - Journal articles
C2 - 31891605
AN - SCOPUS:85077393689
VL - 14
JO - PLoS ONE
JF - PLoS ONE
IS - 12
M1 - e0226893
ER -
