Enhanced psychophysiological signs of attention after angiotensin-converting enzyme inhibition by captopril

Inge Derad; Reinhard Pietrowsky; Christoph Dodt; Horst L. Fehm; Jan Born

doi:10.1111/j.1469-8986.1996.tb00426.x

Enhanced psychophysiological signs of attention after angiotensin-converting enzyme inhibition by captopril

Inge Derad^*, Reinhard Pietrowsky, Christoph Dodt, Horst L. Fehm, Jan Born

^*Corresponding author for this work

Clinic of Internal Medicine I

9 Citations (Scopus)

Abstract

Complementary to its essential role in the central nervous control of cardiovascular activity, the neuropeptide angiotensin II may regulate attentional processes. The present study evaluated central nervous, cardiovascular, and sympathetic indicators of attention after inhibition of angiotensin II synthesis by captopril (50 mg vs. placebo) in 14 men. Event-related potentials (ERPs) and stimulus-related electroencephalographic (EEG) activity were recorded while the subject performed an auditory oddball task. Captopril increased both the N1-P2 component of the ERP (p < .05) and - following the first tone of the task - the EEG desynchronization in the lower alpha frequency band (p < .05). Although blood pressure remained unchanged, heart rate was lowered (p < .05) and plasma norepinephrine concentrations increased (p < .01) after captopril. The effects suggest that inhibition of angiotensin II synthesis enhances an attentional state typically present during sensory intake.

Original language	English
Journal	Psychophysiology
Volume	33
Issue number	3
Pages (from-to)	295-301
Number of pages	7
ISSN	0048-5772
DOIs	https://doi.org/10.1111/j.1469-8986.1996.tb00426.x
Publication status	Published - 05.1996

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title = "Enhanced psychophysiological signs of attention after angiotensin-converting enzyme inhibition by captopril",

abstract = "Complementary to its essential role in the central nervous control of cardiovascular activity, the neuropeptide angiotensin II may regulate attentional processes. The present study evaluated central nervous, cardiovascular, and sympathetic indicators of attention after inhibition of angiotensin II synthesis by captopril (50 mg vs. placebo) in 14 men. Event-related potentials (ERPs) and stimulus-related electroencephalographic (EEG) activity were recorded while the subject performed an auditory oddball task. Captopril increased both the N1-P2 component of the ERP (p < .05) and - following the first tone of the task - the EEG desynchronization in the lower alpha frequency band (p < .05). Although blood pressure remained unchanged, heart rate was lowered (p < .05) and plasma norepinephrine concentrations increased (p < .01) after captopril. The effects suggest that inhibition of angiotensin II synthesis enhances an attentional state typically present during sensory intake.",

author = "Inge Derad and Reinhard Pietrowsky and Christoph Dodt and Fehm, {Horst L.} and Jan Born",

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AU - Derad, Inge

AU - Pietrowsky, Reinhard

AU - Dodt, Christoph

AU - Fehm, Horst L.

AU - Born, Jan

PY - 1996/5

Y1 - 1996/5

N2 - Complementary to its essential role in the central nervous control of cardiovascular activity, the neuropeptide angiotensin II may regulate attentional processes. The present study evaluated central nervous, cardiovascular, and sympathetic indicators of attention after inhibition of angiotensin II synthesis by captopril (50 mg vs. placebo) in 14 men. Event-related potentials (ERPs) and stimulus-related electroencephalographic (EEG) activity were recorded while the subject performed an auditory oddball task. Captopril increased both the N1-P2 component of the ERP (p < .05) and - following the first tone of the task - the EEG desynchronization in the lower alpha frequency band (p < .05). Although blood pressure remained unchanged, heart rate was lowered (p < .05) and plasma norepinephrine concentrations increased (p < .01) after captopril. The effects suggest that inhibition of angiotensin II synthesis enhances an attentional state typically present during sensory intake.

AB - Complementary to its essential role in the central nervous control of cardiovascular activity, the neuropeptide angiotensin II may regulate attentional processes. The present study evaluated central nervous, cardiovascular, and sympathetic indicators of attention after inhibition of angiotensin II synthesis by captopril (50 mg vs. placebo) in 14 men. Event-related potentials (ERPs) and stimulus-related electroencephalographic (EEG) activity were recorded while the subject performed an auditory oddball task. Captopril increased both the N1-P2 component of the ERP (p < .05) and - following the first tone of the task - the EEG desynchronization in the lower alpha frequency band (p < .05). Although blood pressure remained unchanged, heart rate was lowered (p < .05) and plasma norepinephrine concentrations increased (p < .01) after captopril. The effects suggest that inhibition of angiotensin II synthesis enhances an attentional state typically present during sensory intake.

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Enhanced psychophysiological signs of attention after angiotensin-converting enzyme inhibition by captopril

Abstract

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