Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast

Hinnerk Schulz-Hildebrandt, Martin Ahrens, Michael Münter, Elisa Wilken, Tabea Kohlfärber, Cornelia Holzhausen, Peter König, Gereon Hüttmann


Here we present a forward-looking endoscope for dynamic microscopic OCT reaching a lateral resolution of 1.3 µm and 0.8 mm field of view. Since tissue motion degrades dynamic imaging, tissue was immobilized by suction. The endoscope was placed in a 4 mm stainless-steel sheath, which was connected to a vacuum pump. In mice, the endoscope can access various inner organs using open surgery or laparoscopy. The potential of the dynamic endo-microscopic OCT was demonstrated on relevant murine tissue such as liver, spleen and kidney. Otherwise invisible cellular and subcellular structures were imaged by dynamic mOCT with high contrast.
Original languageEnglish
Publication statusPublished - 24.08.2021

Cite this