Emergence of carbapenem-resistant ST131 escherichia coli carrying blaOXA-244 in germany, 2019 to 2020

Sybille Welker; Sébastien Boutin; Thomas Miethke; Klaus Heeg; Dennis Nurjadi

doi:10.2807/1560-7917.ES.2020.25.46.2001815

Emergence of carbapenem-resistant ST131 escherichia coli carrying bla_OXA-244 in germany, 2019 to 2020

Sybille Welker, Sébastien Boutin, Thomas Miethke, Klaus Heeg, Dennis Nurjadi^*

^*Corresponding author for this work

20 Citations (Scopus)

Abstract

The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be underreported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.

Original language	English
Journal	Eurosurveillance
Volume	25
Issue number	46
ISSN	1025-496X
DOIs	https://doi.org/10.2807/1560-7917.ES.2020.25.46.2001815
Publication status	Published - 11.2020

Funding

Funders	Funder number
UK Research and Innovation	106157

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

2.21-03 Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
2.21-05 Immunology

Access to Document

10.2807/1560-7917.ES.2020.25.46.2001815

Cite this

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title = "Emergence of carbapenem-resistant ST131 escherichia coli carrying blaOXA-244 in germany, 2019 to 2020",

abstract = "The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be underreported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.",

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AU - Boutin, Sébastien

AU - Miethke, Thomas

AU - Heeg, Klaus

AU - Nurjadi, Dennis

PY - 2020/11

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N2 - The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be underreported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.

AB - The dissemination of carbapenem-producing Gram-negative bacteria is a major public health concern. We report the first detection of OXA-244-producing ST131 O16:H5 Escherichia coli in three patients from two tertiary hospitals in the south-west of Germany. OXA-244 is emerging in Europe. Because of detection challenges, OXA-244-producing E. coli may be underreported. The emergence of carbapenem resistance in a globally circulating high-risk clone, such as ST131 E. coli is of clinical relevance and should be monitored closely.

UR - https://www.scopus.com/pages/publications/85096459516

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