TY - JOUR
T1 - Elimination half-life of anti-Muellerian hormone
AU - Griesinger, Georg
AU - Dafopoulos, K.
AU - Buendgen, N.
AU - Cascorbi, I.
AU - Georgoulias, P.
AU - Zavos, A.
AU - Messini, C. I.
AU - Messinis, I. E.
PY - 2012/6
Y1 - 2012/6
N2 - CONTEXT: Anti-Müllerian hormone (AMH) is a glycoprotein that is secreted by the granulosa cells in the human ovary. In the postpubertal female, circulating AMH reflects the number of follicles within the ovary. It is mandatory to know the serum elimination half-life (t(1/2)) of AMH to study in vivo short-term changes of the hormone.\n\nOBJECTIVE: Our objective was to determine the kinetics of decay of AMH in the human female.\n\nPATIENTS, DESIGN, AND SETTING: Premenopausal women undergoing total abdominal hysterectomy plus bilateral salpingo-oophorectomy participated in this cohort study (n = 21) at an academic tertiary referral center. Interventions: Serum samples were obtained immediately before surgery and in 12-h intervals thereafter for 8 d.\n\nMAIN OUTCOME MEASURE: AMH elimination was calculated, applying a one-compartment model with first-order kinetics.\n\nRESULTS: Mean preoperative AMH levels were 0.67 ng/ml (range, 0.1-1.78 ng/ml) and dropped to 0.08 ng/ml within 84 h after surgery. The AMH decay followed first-order kinetics. The mean terminal t(1/2) of AMH was calculated as 27.6 ± 0.8 h.\n\nCONCLUSION: AMH elimination reaches approximately 84% after 3 d, approximately 91% after 4 d, approximately 95% after 5 d, and can be considered complete after 8 d.
AB - CONTEXT: Anti-Müllerian hormone (AMH) is a glycoprotein that is secreted by the granulosa cells in the human ovary. In the postpubertal female, circulating AMH reflects the number of follicles within the ovary. It is mandatory to know the serum elimination half-life (t(1/2)) of AMH to study in vivo short-term changes of the hormone.\n\nOBJECTIVE: Our objective was to determine the kinetics of decay of AMH in the human female.\n\nPATIENTS, DESIGN, AND SETTING: Premenopausal women undergoing total abdominal hysterectomy plus bilateral salpingo-oophorectomy participated in this cohort study (n = 21) at an academic tertiary referral center. Interventions: Serum samples were obtained immediately before surgery and in 12-h intervals thereafter for 8 d.\n\nMAIN OUTCOME MEASURE: AMH elimination was calculated, applying a one-compartment model with first-order kinetics.\n\nRESULTS: Mean preoperative AMH levels were 0.67 ng/ml (range, 0.1-1.78 ng/ml) and dropped to 0.08 ng/ml within 84 h after surgery. The AMH decay followed first-order kinetics. The mean terminal t(1/2) of AMH was calculated as 27.6 ± 0.8 h.\n\nCONCLUSION: AMH elimination reaches approximately 84% after 3 d, approximately 91% after 4 d, approximately 95% after 5 d, and can be considered complete after 8 d.
U2 - 10.1210/jc.2012-1070
DO - 10.1210/jc.2012-1070
M3 - Zeitschriftenaufsätze
C2 - 22442264
SN - 0021-972X
VL - 97
SP - 2160
EP - 2163
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 6
ER -
