Elevated MMP-7 levels in patients with systemic sclerosis: Correlation with pulmonary involvement

Pia Moinzadeh*, Thomas Krieg, Martin Hellmich, Jürgen Brinckmann, Elena Neumann, Ulf Müller-Ladner, Alexander Kreuter, Daniel Dumitrescu, Stephan Rosenkranz, Nicolas Hunzelmann

*Corresponding author for this work
    23 Citations (Scopus)


    Background: Fibrosis is characterized by an excessive accumulation of connective tissue because of an imbalance between synthesis and degradation of extracellular matrix proteins. Systemic sclerosis (SSc) is a prototypic chronic inflammatory disease leading to a severe fibrosis of the skin and many internal organs. Questions Addressed: We investigated whether serum MMP-7 levels reflect the activity of the fibrotic reaction in systemic sclerosis. Experimental Design: Serum samples were obtained from 123 patients with systemic sclerosis. MMP-serum levels of all patients with SSc were compared with age-matched healthy controls. Results: Significantly increased median serum MMP-7 levels were found in patients with SSc when compared with controls. The median MMP-7 serum level of patients with lung fibrosis (LF) was significantly higher compared with those without LF. Accordingly, patients with dyspnea and DLCO (diffusion capacity of the lung for carbon monoxide) levels below 60% showed significantly higher median MMP-7 levels. Conclusions: Elevated MMP-7 levels are associated with an advanced stage of SSc and LF. These data suggest that in SSc MMP-7 is involved in the process of fibrotic tissue remodelling.

    Original languageEnglish
    JournalExperimental Dermatology
    Issue number9
    Pages (from-to)770-773
    Number of pages4
    Publication statusPublished - 01.09.2011

    Research Areas and Centers

    • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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