TY - JOUR
T1 - Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast
AU - Serce, Nuran
AU - Gnatzy, Annette
AU - Steiner, Susanne
AU - Lorenzen, Henning
AU - Kirfel, Jutta
AU - Buettner, Reinhard
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - Background: Lysine-specific demethylase1 (LSD1) is a nuclear protein which belongs to the aminooxidase-enzymes playing an important role in controlling gene expression. It has also been found highly expressed in several human malignancies including breast carcinoma. Our aim was to detect LSD1 expression also in pre-invasive neoplasias of the breast. In the current study we therefore analysed LSD1 protein expression in ductal carcinoma in situ (DCIS) in comparison to invasive ductal breast cancer (IDC). Methods. Using immunohistochemistry we systematically analysed LSD1 expression in low grade DCIS (n=27), intermediate grade DCIS (n=30), high grade DCIS (n=31) and in invasive ductal breast cancer (n=32). SPSS version 18.0 was used for statistical analysis. Results: LSD1 was differentially expressed in DCIS and invasive ductal breast cancer. Interestingly, LSD1 was significantly overexpressed in high grade DCIS versus low grade DCIS. Differences in LSD1 expression levels were also statistically significant between low/intermediate DCIS and invasive ductal breast carcinoma. Conclusions: LSD1 is also expressed in pre-invasive neoplasias of the breast. Additionally, there is a gradual increase of LSD1 expression within tumour progression from pre-invasive DCIS to invasive ductal breast carcinoma. Therefore upregulation of LSD1 may be an early tumour promoting event.
AB - Background: Lysine-specific demethylase1 (LSD1) is a nuclear protein which belongs to the aminooxidase-enzymes playing an important role in controlling gene expression. It has also been found highly expressed in several human malignancies including breast carcinoma. Our aim was to detect LSD1 expression also in pre-invasive neoplasias of the breast. In the current study we therefore analysed LSD1 protein expression in ductal carcinoma in situ (DCIS) in comparison to invasive ductal breast cancer (IDC). Methods. Using immunohistochemistry we systematically analysed LSD1 expression in low grade DCIS (n=27), intermediate grade DCIS (n=30), high grade DCIS (n=31) and in invasive ductal breast cancer (n=32). SPSS version 18.0 was used for statistical analysis. Results: LSD1 was differentially expressed in DCIS and invasive ductal breast cancer. Interestingly, LSD1 was significantly overexpressed in high grade DCIS versus low grade DCIS. Differences in LSD1 expression levels were also statistically significant between low/intermediate DCIS and invasive ductal breast carcinoma. Conclusions: LSD1 is also expressed in pre-invasive neoplasias of the breast. Additionally, there is a gradual increase of LSD1 expression within tumour progression from pre-invasive DCIS to invasive ductal breast carcinoma. Therefore upregulation of LSD1 may be an early tumour promoting event.
UR - http://www.scopus.com/inward/record.url?scp=84865296983&partnerID=8YFLogxK
U2 - 10.1186/1472-6890-12-13
DO - 10.1186/1472-6890-12-13
M3 - Journal articles
AN - SCOPUS:84865296983
SN - 1472-6890
VL - 12
JO - BMC Clinical Pathology
JF - BMC Clinical Pathology
M1 - 13
ER -