Ektope Hormonsekretion bei neuroendokrinen Tumoren

Translated title of the contribution: Ectopic hormone secretion by neuroendocrine tumors

C. Hubold*, G. Brabant

*Corresponding author for this work
1 Citation (Scopus)


Ectopic hormone production is a rare complication in neuroendocrine tumors. Tumors producing corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) are most commonly observed, leading to the classical symptoms of Cushing's syndrome. Additionally, a very low percentage of neuroendocrine tumors can produce growth hormone-releasing hormone (GHRH) leading to classical features of acromegaly. Moreover, ectopic antidiuretic hormone (ADH) secretion has been described in neuroendocrine tumors presenting as hyponatremia due to the syndrome of inappropriate ADH secretion. Other ectopic hormone secretions, such as paraneoplastic gonadotropin release are rarely observed. Ectopic hormone secretion is not usually associated with a detectable pituitary mass and diagnosis is based on the measurement of circulating peptides. This is frequently assisted by imaging techniques, such as somatostatin receptor scintigraphy. Therapeutically a curative approach is the primary goal but in advanced tumors palliative treatment aims to control symptoms with the help of specific antihormonal compounds, such as somatostatin analogues.

Translated title of the contributionEctopic hormone secretion by neuroendocrine tumors
Original languageGerman
Issue number2
Pages (from-to)145-151
Number of pages7
Publication statusPublished - 01.02.2012


Dive into the research topics of 'Ectopic hormone secretion by neuroendocrine tumors'. Together they form a unique fingerprint.

Cite this