Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing 
        Pseudomonas aeruginosa.

Kaan Kocer; Truong Nhat My; Bui Tien Sy; Lisa Göpel; Thirumalaisamy P Velavan; Le Huu Song; Silke Peter; Sébastien Boutin; Adesola Olalekan; Dennis Nurjadi

doi:10.1128/aac.00857-25

Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa.

Kaan Kocer, Truong Nhat My, Bui Tien Sy, Lisa Göpel, Thirumalaisamy P Velavan, Le Huu Song, Silke Peter, Sébastien Boutin, Adesola Olalekan, Dennis Nurjadi

4 Citations (Scopus)

Abstract

We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	69
Issue number	11
Pages (from-to)	e0085725
ISSN	0066-4804
DOIs	https://doi.org/10.1128/aac.00857-25
Publication status	Published - 05.11.2025

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 6 Clean Water and Sanitation

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10.1128/aac.00857-25

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Kocer, K., My, T. N., Sy, B. T., Göpel, L., Velavan, T. P., Song, L. H., Peter, S., Boutin, S., Olalekan, A., & Nurjadi, D. (2025). Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 69(11), e0085725. https://doi.org/10.1128/aac.00857-25

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title = "Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa.",

abstract = "We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2\%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa. ",

author = "Kaan Kocer and My, \{Truong Nhat\} and Sy, \{Bui Tien\} and Lisa G{\"o}pel and Velavan, \{Thirumalaisamy P\} and Song, \{Le Huu\} and Silke Peter and S{\'e}bastien Boutin and Adesola Olalekan and Dennis Nurjadi",

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Kocer, K, My, TN, Sy, BT, Göpel, L, Velavan, TP, Song, LH, Peter, S, Boutin, S, Olalekan, A & Nurjadi, D 2025, 'Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa.', Antimicrobial Agents and Chemotherapy, vol. 69, no. 11, pp. e0085725. https://doi.org/10.1128/aac.00857-25

Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa. / Kocer, Kaan; My, Truong Nhat; Sy, Bui Tien et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 69, No. 11, 05.11.2025, p. e0085725.

Research output: Journal Articles › Journal articles › Research › peer-review

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AU - Kocer, Kaan

AU - My, Truong Nhat

AU - Sy, Bui Tien

AU - Göpel, Lisa

AU - Velavan, Thirumalaisamy P

AU - Song, Le Huu

AU - Peter, Silke

AU - Boutin, Sébastien

AU - Olalekan, Adesola

AU - Nurjadi, Dennis

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N2 - We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

AB - We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

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Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa.

Abstract

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