Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing 
        Pseudomonas aeruginosa.

Kaan Kocer; Truong Nhat My; Bui Tien Sy; Lisa Göpel; Thirumalaisamy P Velavan; Le Huu Song; Silke Peter; Sébastien Boutin; Adesola Olalekan; Dennis Nurjadi

doi:10.1128/aac.00857-25

Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa.

Kaan Kocer, Truong Nhat My, Bui Tien Sy, Lisa Göpel, Thirumalaisamy P Velavan, Le Huu Song, Silke Peter, Sébastien Boutin, Adesola Olalekan, Dennis Nurjadi

Abstract

We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Pages (from-to)	e0085725
ISSN	0066-4804
DOIs	https://doi.org/10.1128/aac.00857-25
Publication status	E-pub ahead of print - 10.10.2025

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Kocer, K., My, T. N., Sy, B. T., Göpel, L., Velavan, T. P., Song, L. H., Peter, S., Boutin, S., Olalekan, A., & Nurjadi, D. (2025). Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, e0085725. Advance online publication. https://doi.org/10.1128/aac.00857-25

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abstract = "We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2\%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa. ",

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AU - Kocer, Kaan

AU - My, Truong Nhat

AU - Sy, Bui Tien

AU - Göpel, Lisa

AU - Velavan, Thirumalaisamy P

AU - Song, Le Huu

AU - Peter, Silke

AU - Boutin, Sébastien

AU - Olalekan, Adesola

AU - Nurjadi, Dennis

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N2 - We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

AB - We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, bla NDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-Lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of bla NDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

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ER -

Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa.

Abstract

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