Effekt von Carboplatin und Ifosfamid kombiniert mit lokaler Hyperthermie auf menschliche Mundhöhlenkarzinome im Tiermodell.

C. Brücker; P. Sieg

doi:10.1007/pl00014503

Effekt von Carboplatin und Ifosfamid kombiniert mit lokaler Hyperthermie auf menschliche Mundhöhlenkarzinome im Tiermodell.

Translated title of the contribution: Effect of combined carboplatin and ifosfamide with local hyperthermia on human mouth carcinoma in the animal model

C. Brücker^*, P. Sieg

^*Corresponding author for this work

Clinic of Maxillofacial Surgery

Abstract

The therapeutic efficiency of Carboplatin (CP) and Ifosfamide (IF) with and without local hyperthermia (41 degrees C and 43 degrees C for 60 min respectively) was measured in human-derived oral squamous cell carcinomas (n = 97) growing on the shank of nude mice. Untreated tumors showed exponential tumor growth. The animals were randomly assigned to 10 different treatment groups (n = 9-10). The average tumor volume of the treated animals was compared to the untreated controls and statistically evaluated. CP alone demonstrated only significant growth delay (duration 60 days). IF (62.5 and 125 mg/kg b.w.) alone caused partial tumor regression. Combination of CP or IF with hyperthermia led to significant tumor regression. Tumor-free survival 60 days after treatment was observed as well after application of CP (6 mg/kg b.w.) and hyperthermia (43 degrees C) as well as after IF (125 mg/kg b.w.) and hyperthermia (41 degrees C).

Translated title of the contribution	Effect of combined carboplatin and ifosfamide with local hyperthermia on human mouth carcinoma in the animal model
Original language	German
Journal	Mund-, Kiefer- und Gesichtschirurgie : MKG
Volume	3 Suppl 1
Pages (from-to)	S144-146
ISSN	1432-9417
DOIs	https://doi.org/10.1007/pl00014503
Publication status	Published - 05.1999

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@article{a11190f946f0470aa7c08528ace9b2ee,

title = "Effekt von Carboplatin und Ifosfamid kombiniert mit lokaler Hyperthermie auf menschliche Mundh{\"o}hlenkarzinome im Tiermodell.",

abstract = "The therapeutic efficiency of Carboplatin (CP) and Ifosfamide (IF) with and without local hyperthermia (41 degrees C and 43 degrees C for 60 min respectively) was measured in human-derived oral squamous cell carcinomas (n = 97) growing on the shank of nude mice. Untreated tumors showed exponential tumor growth. The animals were randomly assigned to 10 different treatment groups (n = 9-10). The average tumor volume of the treated animals was compared to the untreated controls and statistically evaluated. CP alone demonstrated only significant growth delay (duration 60 days). IF (62.5 and 125 mg/kg b.w.) alone caused partial tumor regression. Combination of CP or IF with hyperthermia led to significant tumor regression. Tumor-free survival 60 days after treatment was observed as well after application of CP (6 mg/kg b.w.) and hyperthermia (43 degrees C) as well as after IF (125 mg/kg b.w.) and hyperthermia (41 degrees C).",

author = "C. Br{\"u}cker and P. Sieg",

year = "1999",

month = may,

doi = "10.1007/pl00014503",

language = "Deutsch",

volume = "3 Suppl 1",

pages = "S144--146",

journal = "Mund-, Kiefer- und Gesichtschirurgie : MKG",

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TY - JOUR

T1 - Effekt von Carboplatin und Ifosfamid kombiniert mit lokaler Hyperthermie auf menschliche Mundhöhlenkarzinome im Tiermodell.

AU - Brücker, C.

AU - Sieg, P.

PY - 1999/5

Y1 - 1999/5

N2 - The therapeutic efficiency of Carboplatin (CP) and Ifosfamide (IF) with and without local hyperthermia (41 degrees C and 43 degrees C for 60 min respectively) was measured in human-derived oral squamous cell carcinomas (n = 97) growing on the shank of nude mice. Untreated tumors showed exponential tumor growth. The animals were randomly assigned to 10 different treatment groups (n = 9-10). The average tumor volume of the treated animals was compared to the untreated controls and statistically evaluated. CP alone demonstrated only significant growth delay (duration 60 days). IF (62.5 and 125 mg/kg b.w.) alone caused partial tumor regression. Combination of CP or IF with hyperthermia led to significant tumor regression. Tumor-free survival 60 days after treatment was observed as well after application of CP (6 mg/kg b.w.) and hyperthermia (43 degrees C) as well as after IF (125 mg/kg b.w.) and hyperthermia (41 degrees C).

AB - The therapeutic efficiency of Carboplatin (CP) and Ifosfamide (IF) with and without local hyperthermia (41 degrees C and 43 degrees C for 60 min respectively) was measured in human-derived oral squamous cell carcinomas (n = 97) growing on the shank of nude mice. Untreated tumors showed exponential tumor growth. The animals were randomly assigned to 10 different treatment groups (n = 9-10). The average tumor volume of the treated animals was compared to the untreated controls and statistically evaluated. CP alone demonstrated only significant growth delay (duration 60 days). IF (62.5 and 125 mg/kg b.w.) alone caused partial tumor regression. Combination of CP or IF with hyperthermia led to significant tumor regression. Tumor-free survival 60 days after treatment was observed as well after application of CP (6 mg/kg b.w.) and hyperthermia (43 degrees C) as well as after IF (125 mg/kg b.w.) and hyperthermia (41 degrees C).

UR - https://www.scopus.com/pages/publications/0033126989

U2 - 10.1007/pl00014503

DO - 10.1007/pl00014503

M3 - Zeitschriftenaufsätze

C2 - 10414102

AN - SCOPUS:0033126989

SN - 1432-9417

VL - 3 Suppl 1

SP - S144-146

JO - Mund-, Kiefer- und Gesichtschirurgie : MKG

JF - Mund-, Kiefer- und Gesichtschirurgie : MKG

ER -

Effekt von Carboplatin und Ifosfamid kombiniert mit lokaler Hyperthermie auf menschliche Mundhöhlenkarzinome im Tiermodell.

Abstract

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