Effects of isoflurane, enflurane, and halothane on skeletal muscle microcirculation in the endotoxemic rat

Jan Schumacher; Matthies Pörksen; Karl F. Klotz

doi:10.1053/jcrc.2001.21790

Effects of isoflurane, enflurane, and halothane on skeletal muscle microcirculation in the endotoxemic rat

Jan Schumacher^*, Matthies Pörksen, Karl F. Klotz

^*Corresponding author for this work

Department of Anesthesiology and Intensive Care Medicine

11 Citations (Scopus)

Abstract

Purpose: The cardiovascular effects of volatile anesthetics during sepsis sets patients at high risk for hemodynamic deterioration. We compared the microcirculatory alterations in skeletal muscle under anesthesia with isoflurane, enflurane, and halothane in an endotoxemic rat preparation. Materials and Methods: Twenty-one Sprague-Dawley rats under continuous hemodynamic monitoring and intravital microscopy of the spinotrapezius muscle were studied during two level lipopolysaccharide (0.2 mg/kg and 2 mg/kg) induced sepsis. The effects of equianesthetic concentrations (1.5 minimum alveolar concentration [MAC]) of either isoflurane [n:7], enflurane [n:7], or halothane [n:7] on microcirculatory vasoregulation were measured and histopathologic changes were evaluated. Results: During low-dose endotoxemia, arteriolar vasodilation under isoflurane was nearly abolished (P < .05). At high-dose endotoxemia, this lack of vasodilatory effect was similar (P < .05). Animals receiving 1.5 MAC of enflurane during lowdose endotoxin presented a significant decrease in arteriolar diameter by -11.3 (±2.9%), this response was less during high-dose endotoxemia (-7.0, ±2.9%). Halothane caused pronounced vasoconstriction by -20 (±3.7%) during low-dose endotoxemia and moderate but significant constriction during high-dose endotoxemia (-7.9, ±2.6%). Conclusions: Isoflurane, enflurane, and halothane exert significantly different effects on vasoregulation of skeletal muscle arterioles in the endotoxemic rat.

Original language	English
Journal	Journal of Critical Care
Volume	16
Issue number	1
Pages (from-to)	1-7
Number of pages	7
ISSN	0883-9441
DOIs	https://doi.org/10.1053/jcrc.2001.21790
Publication status	Published - 2001

Funding

From the Department of Anesthesiology, Medical University of Luebeck, Luebeck, Germany. Supported by the Medical University of Luebeck, Luebeck, Germany. Received August 28, 2000. Accepted November 1, 2000. Address reprint requests to Jan Sehumacher, MD, Department of Anesthesiology, Medical University of Luebeck, Ratzebarger Allee 160, D-23538 Luebeck, Germany. Copyright 9 2001 by W.B. Saunders Company 0883-9441/01/1601-0001 $35.00/0 doi: lO.1053/jcrc.2001.21790 The authors gratefully acknowledge the support of the Institute of Pathology, Medical University of Luebeck, Germany for the histopathological investigations and the technical support of Dunja Leffler from the Department of Anesthesiology, Medical University of Luebeck.

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10.1053/jcrc.2001.21790

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@article{cd2b66e576d44ec591474726f6475ebe,

title = "Effects of isoflurane, enflurane, and halothane on skeletal muscle microcirculation in the endotoxemic rat",

abstract = "Purpose: The cardiovascular effects of volatile anesthetics during sepsis sets patients at high risk for hemodynamic deterioration. We compared the microcirculatory alterations in skeletal muscle under anesthesia with isoflurane, enflurane, and halothane in an endotoxemic rat preparation. Materials and Methods: Twenty-one Sprague-Dawley rats under continuous hemodynamic monitoring and intravital microscopy of the spinotrapezius muscle were studied during two level lipopolysaccharide (0.2 mg/kg and 2 mg/kg) induced sepsis. The effects of equianesthetic concentrations (1.5 minimum alveolar concentration [MAC]) of either isoflurane [n:7], enflurane [n:7], or halothane [n:7] on microcirculatory vasoregulation were measured and histopathologic changes were evaluated. Results: During low-dose endotoxemia, arteriolar vasodilation under isoflurane was nearly abolished (P < .05). At high-dose endotoxemia, this lack of vasodilatory effect was similar (P < .05). Animals receiving 1.5 MAC of enflurane during lowdose endotoxin presented a significant decrease in arteriolar diameter by -11.3 (±2.9\%), this response was less during high-dose endotoxemia (-7.0, ±2.9\%). Halothane caused pronounced vasoconstriction by -20 (±3.7\%) during low-dose endotoxemia and moderate but significant constriction during high-dose endotoxemia (-7.9, ±2.6\%). Conclusions: Isoflurane, enflurane, and halothane exert significantly different effects on vasoregulation of skeletal muscle arterioles in the endotoxemic rat.",

author = "Jan Schumacher and Matthies P{\"o}rksen and Klotz, \{Karl F.\}",

note = "Funding Information: From the Department of Anesthesiology, Medical University of Luebeck, Luebeck, Germany. Supported by the Medical University of Luebeck, Luebeck, Germany. Received August 28, 2000. Accepted November 1, 2000. Address reprint requests to Jan Sehumacher, MD, Department of Anesthesiology, Medical University of Luebeck, Ratzebarger Allee 160, D-23538 Luebeck, Germany. Copyright 9 2001 by W.B. Saunders Company 0883-9441/01/1601-0001 \$35.00/0 doi: lO.1053/jcrc.2001.21790 Funding Information: The authors gratefully acknowledge the support of the Institute of Pathology, Medical University of Luebeck, Germany for the histopathological investigations and the technical support of Dunja Leffler from the Department of Anesthesiology, Medical University of Luebeck. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2001",

doi = "10.1053/jcrc.2001.21790",

language = "English",

volume = "16",

pages = "1--7",

journal = "Journal of Critical Care",

issn = "0883-9441",

publisher = "W.B. Saunders",

number = "1",

}

TY - JOUR

T1 - Effects of isoflurane, enflurane, and halothane on skeletal muscle microcirculation in the endotoxemic rat

AU - Schumacher, Jan

AU - Pörksen, Matthies

AU - Klotz, Karl F.

N1 - Funding Information: From the Department of Anesthesiology, Medical University of Luebeck, Luebeck, Germany. Supported by the Medical University of Luebeck, Luebeck, Germany. Received August 28, 2000. Accepted November 1, 2000. Address reprint requests to Jan Sehumacher, MD, Department of Anesthesiology, Medical University of Luebeck, Ratzebarger Allee 160, D-23538 Luebeck, Germany. Copyright 9 2001 by W.B. Saunders Company 0883-9441/01/1601-0001 $35.00/0 doi: lO.1053/jcrc.2001.21790 Funding Information: The authors gratefully acknowledge the support of the Institute of Pathology, Medical University of Luebeck, Germany for the histopathological investigations and the technical support of Dunja Leffler from the Department of Anesthesiology, Medical University of Luebeck. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2001

Y1 - 2001

N2 - Purpose: The cardiovascular effects of volatile anesthetics during sepsis sets patients at high risk for hemodynamic deterioration. We compared the microcirculatory alterations in skeletal muscle under anesthesia with isoflurane, enflurane, and halothane in an endotoxemic rat preparation. Materials and Methods: Twenty-one Sprague-Dawley rats under continuous hemodynamic monitoring and intravital microscopy of the spinotrapezius muscle were studied during two level lipopolysaccharide (0.2 mg/kg and 2 mg/kg) induced sepsis. The effects of equianesthetic concentrations (1.5 minimum alveolar concentration [MAC]) of either isoflurane [n:7], enflurane [n:7], or halothane [n:7] on microcirculatory vasoregulation were measured and histopathologic changes were evaluated. Results: During low-dose endotoxemia, arteriolar vasodilation under isoflurane was nearly abolished (P < .05). At high-dose endotoxemia, this lack of vasodilatory effect was similar (P < .05). Animals receiving 1.5 MAC of enflurane during lowdose endotoxin presented a significant decrease in arteriolar diameter by -11.3 (±2.9%), this response was less during high-dose endotoxemia (-7.0, ±2.9%). Halothane caused pronounced vasoconstriction by -20 (±3.7%) during low-dose endotoxemia and moderate but significant constriction during high-dose endotoxemia (-7.9, ±2.6%). Conclusions: Isoflurane, enflurane, and halothane exert significantly different effects on vasoregulation of skeletal muscle arterioles in the endotoxemic rat.

AB - Purpose: The cardiovascular effects of volatile anesthetics during sepsis sets patients at high risk for hemodynamic deterioration. We compared the microcirculatory alterations in skeletal muscle under anesthesia with isoflurane, enflurane, and halothane in an endotoxemic rat preparation. Materials and Methods: Twenty-one Sprague-Dawley rats under continuous hemodynamic monitoring and intravital microscopy of the spinotrapezius muscle were studied during two level lipopolysaccharide (0.2 mg/kg and 2 mg/kg) induced sepsis. The effects of equianesthetic concentrations (1.5 minimum alveolar concentration [MAC]) of either isoflurane [n:7], enflurane [n:7], or halothane [n:7] on microcirculatory vasoregulation were measured and histopathologic changes were evaluated. Results: During low-dose endotoxemia, arteriolar vasodilation under isoflurane was nearly abolished (P < .05). At high-dose endotoxemia, this lack of vasodilatory effect was similar (P < .05). Animals receiving 1.5 MAC of enflurane during lowdose endotoxin presented a significant decrease in arteriolar diameter by -11.3 (±2.9%), this response was less during high-dose endotoxemia (-7.0, ±2.9%). Halothane caused pronounced vasoconstriction by -20 (±3.7%) during low-dose endotoxemia and moderate but significant constriction during high-dose endotoxemia (-7.9, ±2.6%). Conclusions: Isoflurane, enflurane, and halothane exert significantly different effects on vasoregulation of skeletal muscle arterioles in the endotoxemic rat.

UR - https://www.scopus.com/pages/publications/0035092023

U2 - 10.1053/jcrc.2001.21790

DO - 10.1053/jcrc.2001.21790

M3 - Journal articles

C2 - 11230718

AN - SCOPUS:0035092023

SN - 0883-9441

VL - 16

SP - 1

EP - 7

JO - Journal of Critical Care

JF - Journal of Critical Care

IS - 1

ER -

Effects of isoflurane, enflurane, and halothane on skeletal muscle microcirculation in the endotoxemic rat

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